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The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells.
|Cat. No.||Product Name / Activity|
|Na+/Ca2+ exchanger inhibitor; also Kv11.1 (hERG) channel blocker|
|NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative|
|Na+/Ca2+ exchange inhibitor. Also Ca2+ channel blocker|
|Antagonist of mitochondrial Na+/Ca2+ exchange|
|Mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor|
|Na+/Ca2+ exchange inhibitor (reverse mode)|
|Potent Na+/Ca2+ exchanger (NCX) inhibitor|
|Selective Na+/Ca2+ exchange inhibitor (reverse mode)|
|Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective|
The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells. Using the electrochemical gradient of Na+, one Ca2+ ion is transported out of the cell in exchange for three Na+ ions.
The Na+/Ca2+ exchanger compliments the high affinity, low capacitance Ca2+-ATPase and together, they are involved in a variety of cellular functions including control of neurosecretion, relaxation of cardiac muscle, maintenance of intracellular Ca2+ stores in the endoplasmic and sarcoplasmic reticuli and excitation-contraction coupling. Under normal physiological conditions, Na+/Ca2+ exchangers export Ca+ from the cell. However, under cellular stress, such as excitotoxicity, they can switch to 'reverse mode,' which has a protective effect.
Tocris offers the following scientific literature for Na+/Ca2+ Exchanger to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|