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The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells.
|Cat. No.||Product Name / Activity|
|Na+/Ca2+ exchanger inhibitor; also Kv11.1 (hERG) channel blocker|
|NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative|
|Na+/Ca2+ exchange inhibitor. Also Ca2+ channel blocker|
|Antagonist of mitochondrial Na+/Ca2+ exchange|
|Mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor|
|Na+/Ca2+ exchange inhibitor (reverse mode)|
|Potent Na+/Ca2+ exchanger (NCX) inhibitor|
|Selective Na+/Ca2+ exchange inhibitor (reverse mode)|
|Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective|
The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells. Using the electrochemical gradient of Na+, one Ca2+ ion is transported out of the cell in exchange for three Na+ ions.
The Na+/Ca2+ exchanger compliments the high affinity, low capacitance Ca2+-ATPase and together, they are involved in a variety of cellular functions including control of neurosecretion, relaxation of cardiac muscle, maintenance of intracellular Ca2+ stores in the endoplasmic and sarcoplasmic reticuli and excitation-contraction coupling. Under normal physiological conditions, Na+/Ca2+ exchangers export Ca+ from the cell. However, under cellular stress, such as excitotoxicity, they can switch to 'reverse mode,' which has a protective effect.
|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|