CP 43

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Description: Potent TAOK inhibitor
Chemical Name: N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for CP 43

CP 43 is a potent TAO kinase (TAOK) inhibitor (IC50 values are 11 nM/L and 15 nM/L for TAOK1 and TAOK2, respectively). Inhibits TAOK phosphorylation and activation of JNK in vitro. Prolongs duration of mitosis and increases mitotic cell death in the SKBR3 breast cancer cell line. Also reduces tau phopshorylation in cortical neurons at sites associated with neurodegeneration in human tauopathies.

Compound Libraries for CP 43

CP 43 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for CP 43

M. Wt 384.47
Formula C25H24N2O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 850467-66-2
PubChem ID 46673962
Smiles O=C(NC1CCCC2=CC=CC=C12)CNC(C3=CC=C(C4=CC=CC=C4)C=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CP 43

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 38.45 100
ethanol 7.69 20

Preparing Stock Solutions for CP 43

The following data is based on the product molecular weight 384.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.6 mL 13 mL 26.01 mL
5 mM 0.52 mL 2.6 mL 5.2 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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References for CP 43

References are publications that support the biological activity of the product.

Koo et al (2017) Targeting TAO kinase using a new inhibitor compound delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells. Mol.Cancer Ther. 16 2410 PMID: 28830982

Giacomini et al (2018) A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies. Acta Neuropathol.Commun. 6 37 PMID: 29730992

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Keywords: CP 43, CP 43 supplier, CP43, TAOK, TAOK1, TAOK2, TAO, thousand, and, one, amino, acid, kinase, inhibitors, inhibits, potent, JNK, activation, Other, Kinases, JNK/c-jun, 6558, Tocris Bioscience

1 Citation for CP 43

Citations are publications that use Tocris products. Selected citations for CP 43 include:

Smita et al (2021) TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules. Dev Cell 56 3321-3333.e5 PMID: 34879262

Do you know of a great paper that uses CP 43 from Tocris? Please let us know.

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