p38 MAPK

p38 kinases are a group of mitogen-activated protein kinases (MAPKs). Like JNK/c-Jun, the p38 kinases are responsive to stresses such as osmotic shock and cytokine stimulation; consequently they are also classified as stress-activated protein kinases (SAPKs).

Products
Background
Literature
Pathways
Gene Data

Inhibitors

Cat No Product Name / Activity
4753 AL 8697
Potent and selective p38α inhibitor
3920 AMG 548
Potent and selective p38α inhibitor
5989 BIRB 796
High affinity and selective p38 kinase inhibitor
2186 CMPD-1
Selective inhibitor of p38α-mediated MK2a phosphorylation; also tubulin polymerization inhibitor
5095 DBM 1285 dihydrochloride
p38 MAPK inhibitor; anti-inflammatory
2908 EO 1428
Selective inhibitor of p38α and p38β2
2657 JX 401
Potent, reversible p38α inhibitor
4586 ML 3403
p38 inhibitor
6014 Org 48762-0
Selective p38α/β inhibitor; orally bioavailable
5866 PH 797804
Potent and selective p38α/β inhibitor
2999 RWJ 67657
Potent, selective p38α and p38β inhibitor
1264 SB 202190
Potent, selective inhibitor of p38 MAPK
1202 SB 203580
Selective inhibitor of p38 MAPK
1402 SB 203580 hydrochloride
Selective inhibitor of p38 MAPK; water-soluble
1962 SB 239063
Potent, selective p38 MAPK inhibitor; orally active
5040 SB 706504
p38 MAPK inhibitor
3528 SCIO 469 hydrochloride
Selective p38 MAPK inhibitor
2008 SKF 86002 dihydrochloride
p38 MAPK inhibitor; anti-inflammatory agent
3639 SX 011
p38 MAPK inhibitor
5383 TA 01
p38α inhibitor; also inhibits CK1ε and CK1δ
5384 TA 02
p38α inhibitor; also inhibits CK1ε and CK1δ
4254 TAK 715
Potent p38 MAPK inhibitor; anti-inflammatory
3916 VX 702
Orally active p38α and p38β inhibitor
3915 VX 745
Potent and selective p38α inhibitor

Ligand-sets

Cat No Product Name / Activity
2244 p38 MAPK Inhibitor Tocriset™
Selection of 3 p38 MAPK inhibitors (Cat. Nos. 1264, 1202 and 1962)

p38 kinases are a group of mitogen-activated protein kinases (MAPKs). Like JNK/c-Jun, the p38 kinases are responsive to stress stimuli such as osmotic shock and cytokine stimulation; they are also classified as stress-activated protein kinases (SAPKs). p38 also responds to insulin and growth factor stimulation and is often activated during normal immune and inflammatory responses. The active form of p38 phosphorylates specific cellular targets and also regulates gene expression via activation of specific transcription factors.

There are four isoforms of p38: α-, β-, γ- and δ. p38α and β are ubiquitously expressed, while the expression of p38γ and p38δ varies between tissue types. Activation of p38α is dependent on both stimulus and cell type; however, all isoforms of p38 are activated by MAPKKs - in particular, MKK3 and MKK6. Downstream targets of p38α and β include protein kinases such as MAPKAPK2 (MK2) and MNK1, and a range of transcription factors.

p38 has been linked to numerous cellular processes, including inflammation, apoptosis, and the cell cycle. In recent years, p38 has been isolated as a major therapeutic target for the treatment of rheumatoid arthritis.

Literature for p38 MAPK

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for p38 MAPK

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

p38 MAPK Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
p38α Human MAPK14 NM_001315 Q16539
Mouse Mapk14 NM_011951 P47811
Rat Mapk14 NM_031020 P70618
p38β Human MAPK11 NM_002751 Q15759
Mouse Mapk11 NM_011161 Q9WUI1
p38δ Human MAPK13 NM_002754 O15264
Mouse Mapk13 NM_011950 Q9Z1B7
Rat Mapk13 NM_019231 Q32Q45
p38γ Human MAPK12 NM_002969 P53778
Mouse Mapk12 NM_013871 O08911
Rat Mapk12 NM_021746 Q63538