Cytokine and NF-κB Signaling

Cytokine and NF-κB signaling pathways are intricately linked biochemical cascades that are involved in the innate and adaptive immune response, inflammation and stress responses.

Targets
Literature
Pathways

Cytokine and NF-κB Signaling Target Files

Proinflammatory cytokines, such as IFNγ and TNFα, activate the IKK complex, which phosphorylates IκB and targets it for proteasomal degradation. This frees NF-κB and, after phosphorylation, allows it to translocate to the nucleus. In the nucleus NF-κB acts alone, or with other transcription factors such as AP-1 and STAT, to induce target gene expression.

In addition to activation by cytokines, this pathway can be activated by cellular stresses such as UV light and ischemia. JNK (also known as stress-activated protein kinase) activates NF-κB and allows target gene expression. Similarly, JAK, which is associated with cytokine receptors, phosphorylates STAT and enhances NF-κB-STAT-mediated gene expression.

Literature for Cytokine and NF-κB Signaling

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for Cytokine and NF-κB Signaling

NF-κB

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.