TCS JNK 6o

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Cat.No. 3222 - TCS JNK 6o | C18H20N4O4 | CAS No. 894804-07-0
Description: Selective JNK inhibitor
Chemical Name: N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature
Pathways

Biological Activity

ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 values are 2, 4 and 52 nM for JNK1, JNK2 and JNK3 respectively). Displays > 1000 fold selectivity over other kinases, including ERK2 and p38. Inhibits c-Jun phosphorylation (EC50 = 920 nM) and prevents collagen-induced platelet aggregation in vitro.

Technical Data

M. Wt 356.38
Formula C18H20N4O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 894804-07-0
PubChem ID 11624601
InChI Key KQMPRSZTUSSXND-UHFFFAOYSA-N
Smiles CCOC1=NC(NC(=O)CC2=CC(OC)=CC=C2OC)=CC(N)=C1C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 356.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.03 mL 28.06 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
10 mM 0.28 mL 1.4 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Szczepankiewicz et al (2006) Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J.Med.Chem. 49 3563 PMID: 16759099

Kauskot et al (2007) Involvement of the mirogen-activated protein kinase c-Jun NH2-terminal kinase 1 in thrombus formation. J.Biol.Chem. 282 31990 PMID: 17785464


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View Related Products by Product Action

View all JNK/c-Jun Inhibitors

Keywords: TCS JNK 6o, TCS JNK 6o supplier, TCSJNK6o, c-Jun, N-terminal, kinase, JNK, inhibitors, inhibits, JNK1, JNK2, JNK3, JNK/c-jun, 3222, Tocris Bioscience

3 Citations for TCS JNK 6o

Citations are publications that use Tocris products. Selected citations for TCS JNK 6o include:

Xiao et al (2019) Targeting JNK pathway promotes human hematopoietic stem cell expansion. Cell Discov 5 2 PMID: 30622738

Souvannaseng et al (2018) Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection. PLoS Pathog 14 e1007418 PMID: 30496310

Yang et al (2017) Establishment of mouse expanded potential stem cells. Nature 550 393 PMID: 29019987


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

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Kinases Product Listing

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MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for TCS JNK 6o

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.