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TCS JNK 6o
Biological Activity for TCS JNK 6o
TCS JNK 6o is an ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 values are 2, 4 and 52 nM for JNK1, JNK2 and JNK3 respectively). Displays > 1000 fold selectivity over other kinases, including ERK2 and p38. Inhibits c-Jun phosphorylation (EC50 = 920 nM) and prevents collagen-induced platelet aggregation in vitro.
Technical Data for TCS JNK 6o
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TCS JNK 6o
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TCS JNK 6o
The following data is based on the product molecular weight 356.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.81 mL||14.03 mL||28.06 mL|
|5 mM||0.56 mL||2.81 mL||5.61 mL|
|10 mM||0.28 mL||1.4 mL||2.81 mL|
|50 mM||0.06 mL||0.28 mL||0.56 mL|
References for TCS JNK 6o
References are publications that support the biological activity of the product.
Szczepankiewicz et al (2006) Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J.Med.Chem. 49 3563 PMID: 16759099
Kauskot et al (2007) Involvement of the mirogen-activated protein kinase c-Jun NH2-terminal kinase 1 in thrombus formation. J.Biol.Chem. 282 31990 PMID: 17785464
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Keywords: TCS JNK 6o, TCS JNK 6o supplier, TCSJNK6o, c-Jun, N-terminal, kinase, JNK, inhibitors, inhibits, JNK1, JNK2, JNK3, JNK/c-jun, 3222, Tocris Bioscience
3 Citations for TCS JNK 6o
Citations are publications that use Tocris products. Selected citations for TCS JNK 6o include:
Souvannaseng et al (2018) Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection. PLoS Pathog 14 e1007418 PMID: 30496310
Yang et al (2017) Establishment of mouse expanded potential stem cells. Nature 550 393 PMID: 29019987
Xiao et al (2019) Targeting JNK pathway promotes human hematopoietic stem cell expansion. Cell Discov 5 2 PMID: 30622738
Do you know of a great paper that uses TCS JNK 6o from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.