Cyclooxygenases
Cyclooxygenase (also known as COX, Prostaglandin-endoperoxide synthase, Prostaglandin G/H synthase) is expressed in cells in three isoforms. COX-1 (constitutive) and COX-2 (inducible) isoforms catalyze the rate-limiting step of prostaglandin production.
Cyclooxygenase Inhibitors |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 1706 | Acetaminophen |
| Cyclooxygenase inhibitor; may be selective for COX-3 | |
| 4092 | Aspirin |
| Cyclooxygenase inhibitor; NSAID | |
| 3786 | Celecoxib |
| Selective cyclooxygenase-2 (COX-2) inhibitor | |
| 4454 | Diclofenac sodium salt |
| Cyclooxygenase inhibitor; NSAID | |
| 1430 | DuP 697 |
| Cyclooxygenase-2 (COX-2) inhibitor | |
| 4522 | Flufenamic acid |
| Cyclooxygenase inhibitor; NSAID. Also activates TRPC6 | |
| 1507 | FR 122047 hydrochloride |
| Cyclooxygenase (COX-1) inhibitor | |
| 1708 | Indomethacin |
| Cyclooxygenase inhibitor (COX-1 > COX-2) | |
| 0942 | NS 398 |
| Cyclooxygenase-2 (COX-2) inhibitor | |
| 1418 | Resveratrol |
| Cyclooxygenase inhibitor | |
| 1550 | SC 560 |
| Cyclooxygenase-1 (COX-1) inhibitor | |
| 3919 | SC 236 |
| Selective cyclooxygenase-2 (COX-2) inhibitor | |
| 2580 | Tenidap |
| NSAID, cyclooxygenase (COX-1) inhibitor. Also opener of KIR2.3 | |
| 4206 | Valdecoxib |
| Selective and potent COX-2 inhibitor | |
Cyclooxygenase (also known as COX, Prostaglandin-endoperoxide synthase, Prostaglandin G/H synthase) is expressed in cells in three isoforms: COX-1, COX-2 and COX-3. COX-1 (constitutive) and COX-2 (inducible) isoforms catalyze the rate-limiting step of prostaglandin production and are the targets of non-steroidal anti-inflammatory drugs. COX-3 does not appear to be involved in inflammatory processes, but seems to be involved in pain and fever. COX-3 is thought to be derived through the retention of the highly structured G + C-rich intron 1 of the COX-1 gene.
External sources of pharmacological information for Cyclooxygenases :
Literature for Cyclooxygenases
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