Gonadotropin-Releasing Hormone Receptors

Gonadotropin-releasing hormone (GnRH) receptors are a group of Gq/11-protein-coupled receptors that are divided into two subtypes; GnRH and GnRH2. GnRH receptors are predominantly expressed by pituitary gonadotrophs. GnRH2 is silenced in humans.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
3592 Goserelin acetate
GnRH receptor agonist
2873 Leuprolide
GnRH receptor agonist
2544 Nafarelin
GnRH receptor agonist

Antagonists

Cat No Product Name / Activity
2730 AG 045572
Selective GnRH receptor antagonist
3536 Cetrorelix Acetate
Potent GnRH receptor antagonist
2519 T 98475
GnRH receptor antagonist
3890 WAY 207024 dihydrochloride
GnRH receptor antagonist

Gonadotropin-releasing hormone (GnRH) receptors are a group of Gq/11-protein-coupled receptors that are divided into two subtypes; GnRH and GnRH2. GnRH receptors are predominantly expressed by pituitary gonadotrophs and are found at lower concentrations in the ovary, breast, placenta, prostate, heart and kidneys.

GnRH regulates the biosynthesis and secretion of follicle-stimulating hormone (FSH) and luteinising hormone (LH) and the human gene encoding the GnRH receptor is localized on chromosome 4q21.2. GnRH2 is silenced in humans but in other mammals it stimulates sexual behavior and has neuromodulatory activity.

External sources of pharmacological information for Gonadotropin-Releasing Hormone Receptors :

Literature for Gonadotropin-Releasing Hormone Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing

Gonadotropin-Releasing Hormone Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
GnRH Human GNRHR NM_000406 P30968
Mouse Gnrhr NM_010323 Q01776
Rat Gnrhr NM_031038 P30969
GnRH2 Human GNRHR2 NR_002328 Q96P88