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Gonadotropin-Releasing Hormone Receptors

Gonadotropin-releasing hormone (GnRH) receptors are a group of Gq/11-protein-coupled receptors that are divided into two subtypes; GnRH and GnRH2. GnRH receptors are predominantly expressed by pituitary gonadotrophs. GnRH2 is silenced in humans.

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Background
Literature (2)
Gene Data

Gonadotropin-Releasing Hormone Receptor Antagonists
Cat. No. Product Name / Activity
3536 Cetrorelix Acetate
Potent GnRH receptor antagonist

Gonadotropin-releasing hormone (GnRH) receptors are a group of Gq/11-protein-coupled receptors that are divided into two subtypes; GnRH and GnRH2. GnRH receptors are predominantly expressed by pituitary gonadotrophs and are found at lower concentrations in the ovary, breast, placenta, prostate, heart and kidneys.

GnRH regulates the biosynthesis and secretion of follicle-stimulating hormone (FSH) and luteinising hormone (LH) and the human gene encoding the GnRH receptor is localized on chromosome 4q21.2. GnRH2 is silenced in humans but in other mammals it stimulates sexual behavior and has neuromodulatory activity.

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Literature for Gonadotropin-Releasing Hormone Receptors

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GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors Product Listing

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing

Gonadotropin-Releasing Hormone Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
GnRH Human GNRHR NM_000406 P30968
Mouse Gnrhr NM_010323 Q01776
Rat Gnrhr NM_031038 P30969
GnRH2 Human GNRHR2 NR_002328 Q96P88