SU 3327

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Cat.No. 3607 - SU 3327 | C5H3N5O2S3 | CAS No. 40045-50-9
Description: Selective JNK inhibitor
Alternative Names: Halicin
Chemical Name: 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (4)
Pathways (1)

Biological Activity

Selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM). Inhibits the protein-protein interaction between JNK and JIP (IC50 = 239 nM). Displays selectivity over p38 MAPK and Akt. Restores insulin sensitivity in a mouse model of type-2 diabetes. Displays antibiotic activity against a range of bacteria including S.aureus, A.baumanni, C.difficile and M.tuberculosis.

Compound Libraries

SU 3327 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 261.3
Formula C5H3N5O2S3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 40045-50-9
PubChem ID 11837140
InChI Key NQQBNZBOOHHVQP-UHFFFAOYSA-N
Smiles NC2=NN=C(S2)SC1=NC=C([N+]([O-])=O)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.13 100
ethanol 2.61 10

Preparing Stock Solutions

The following data is based on the product molecular weight 261.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.83 mL 19.14 mL 38.27 mL
5 mM 0.77 mL 3.83 mL 7.65 mL
10 mM 0.38 mL 1.91 mL 3.83 mL
50 mM 0.08 mL 0.38 mL 0.77 mL

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References

References are publications that support the biological activity of the product.

De et al (2009) Design, synthesis and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-jun N-terminal kinase. J.Med.Chem. 52 1943 PMID: 19271755


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View Related Products by Product Action

View all JNK/c-Jun Inhibitors

Keywords: SU 3327, SU 3327 supplier, SU3327, JNK, kinases, inhibitors, inhibits, selective, MAPK, Signaling, Signalling, c-Jun, N-Terminal, SAPKs, Stress-Activated, Protein, Mitogen-Activated, Halicin, antibiotic, JNK/c-jun, Antibiotics, 3607, Tocris Bioscience

3 Citations for SU 3327

Citations are publications that use Tocris products. Selected citations for SU 3327 include:

Shaw and Lloyd (2012) Post-transcriptional regulation of placenta growth factor mRNA by hydrogen peroxide. Redox Biol 84 155 PMID: 22683469

Lo et al (2014) TNF-α induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways. Acta Pharmacol Sin 35 339 PMID: 24487964

Jang et al (2015) Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury. J Biol Chem 6 552 PMID: 26491845


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

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Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for SU 3327

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.