CEP 1347

Pricing Availability Delivery Time Qty
Cat.No. 4924 - CEP 1347 | C33H33N3O5S2 | CAS No. 156177-65-0
Description: Inhibitor of JNK signaling
Chemical Name: (9S,10R,12R)-5-16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Inhibitor of c-jun N-terminal kinase (JNK) signaling. Rescues motor neurons undergoing apoptosis (EC50 = 20 nM). Blocks Aβ-induced cortical neuron apoptosis (EC50 ~51 nM). Does not inhibit ERK1 activity. Neuroprotective.

Technical Data

M. Wt 615.76
Formula C33H33N3O5S2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 156177-65-0
PubChem ID 9917013
InChI Key SCMLRESZJCKCTC-KMYQRJGFSA-N
Smiles O=C(NC8)C1=C8C(C(C=C(CSCC)C=C7)=C7N45)=C4C2=C1C6=C(C=CC(CSCC)=C6)N2[C@H]3C[C@](O)([C@](OC)=O)[C@]5(C)O3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.16 10

Preparing Stock Solutions

The following data is based on the product molecular weight 615.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.62 mL 8.12 mL 16.24 mL
5 mM 0.32 mL 1.62 mL 3.25 mL
10 mM 0.16 mL 0.81 mL 1.62 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Maroney et al (1998) Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway. J.Neurosci. 18 104 PMID: 9412490

Bozyczko-Coyne et al (2001) CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis. J.Neurochem. 77 849 PMID: 11331414

Saporito et al (1998) Preservation of cholinergic activity and prevention of neuron death by CEP-1347/KT-7515 following excitotoxic injury of the nucleus basalis magnocellularis. Neuroscience 86 461 PMID: 9881861


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View all JNK/c-Jun Inhibitors

Keywords: CEP 1347, supplier, CEP1347, inhibitors, inhibits, JNK, signaling, Mitogen-Activated, Protein, Kinases, c-Jun, N-Terminal, SAPKs, Stress-Activated, amyloidbeta, amyloidb, amyloidβ, JNK/c-jun, Amyloid, Beta, Peptides, JNK/c-jun, Tocris Bioscience

Citations for CEP 1347

Citations are publications that use Tocris products.

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Literature in this Area

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for CEP 1347

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

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