Pricing Availability   Qty
Description: Selective inhibitor of JNK2 and JNK3
Chemical Name: N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide
Purity: ≥99% (HPLC)
Literature (1)
Pathways (1)

Biological Activity for TCS JNK 5a

TCS JNK 5a is a selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α respectively). Displays no significant activity at a range of other protein kinases including EGFR, ErbB2, cdk2, PLK-1 and Src (pIC50 < 5.0).

Compound Libraries for TCS JNK 5a

TCS JNK 5a is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for TCS JNK 5a

M. Wt 332.42
Formula C20H16N2OS
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 312917-14-9
PubChem ID 766949
Smiles O=C(C3=CC=CC4=C3C=CC=C4)NC2=C(C#N)C1=C(S2)CCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TCS JNK 5a

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.24 100

Preparing Stock Solutions for TCS JNK 5a

The following data is based on the product molecular weight 332.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.04 mL 30.08 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
10 mM 0.3 mL 1.5 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for TCS JNK 5a

Certificate of Analysis / Product Datasheet
Select another batch:

References for TCS JNK 5a

References are publications that support the biological activity of the product.

Angell et al (2007) N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg.Med.Chem.Letts. 17 1296 PMID: 17194588

If you know of a relevant reference for TCS JNK 5a, please let us know.

View Related Products by Product Action

View all JNK/c-Jun Inhibitors

Keywords: TCS JNK 5a, TCS JNK 5a supplier, Selective, inhibitors, inhibits, JNK2, JNK3, Mitogen-Activated, Protein, Kinases, MAPK, c-Jun, N-Terminal, SAPKs, Stress-Activated, TCSJNK5a, JNK/c-jun, 2827, Tocris Bioscience

Citations for TCS JNK 5a

Citations are publications that use Tocris products.

Currently there are no citations for TCS JNK 5a. Do you know of a great paper that uses TCS JNK 5a from Tocris? Please let us know.

Reviews for TCS JNK 5a

There are currently no reviews for this product. Be the first to review TCS JNK 5a and earn rewards!

Have you used TCS JNK 5a?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for TCS JNK 5a

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.