TCS JNK 5a

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Cat.No. 2827 - TCS JNK 5a | C20H16N2OS | CAS No. 312917-14-9
Description: Selective inhibitor of JNK2 and JNK3
Chemical Name: N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (4)
Pathways (1)

Biological Activity for TCS JNK 5a

TCS JNK 5a is a selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α respectively). Displays no significant activity at a range of other protein kinases including EGFR, ErbB2, cdk2, PLK-1 and Src (pIC50 < 5.0).

Compound Libraries for TCS JNK 5a

TCS JNK 5a is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for TCS JNK 5a

M. Wt 332.42
Formula C20H16N2OS
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 312917-14-9
PubChem ID 766949
InChI Key WQGDQGAFSDMBLA-UHFFFAOYSA-N
Smiles O=C(C3=CC=CC4=C3C=CC=C4)NC2=C(C#N)C1=C(S2)CCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TCS JNK 5a

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.24 100

Preparing Stock Solutions for TCS JNK 5a

The following data is based on the product molecular weight 332.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.04 mL 30.08 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
10 mM 0.3 mL 1.5 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets for TCS JNK 5a

Certificate of Analysis / Product Datasheet
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References for TCS JNK 5a

References are publications that support the biological activity of the product.

Angell et al (2007) N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg.Med.Chem.Letts. 17 1296 PMID: 17194588


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View all JNK/c-Jun Inhibitors

Keywords: TCS JNK 5a, TCS JNK 5a supplier, Selective, inhibitors, inhibits, JNK2, JNK3, Mitogen-Activated, Protein, Kinases, MAPK, c-Jun, N-Terminal, SAPKs, Stress-Activated, TCSJNK5a, JNK/c-jun, 2827, Tocris Bioscience

Citations for TCS JNK 5a

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Pathways for TCS JNK 5a

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.