Cytokines

Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Products
Background
Literature
Gene Data
Cat No Product Name / Activity
2446 AS 101
Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1α, IL-2 and TNF-α release
5430 AS 2444697
Potent and selective IRAK4 inhibitor
4316 Bropirimine
Immunomodulatory and antitumor compound
4204 BTZO 1
MIF binder
5484 C 87
TNF-α inhibitor
0846 Chicago Sky Blue 6B
MIF inhibitor; also inhibits L-glutamate uptake into synaptic vesicles
6107 CP 424174
Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3
4400 (±)-CPSI 1306
Reported macrophage migration inhibitory factor (MIF) inhibitor
5479 CRID3 sodium salt
Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production
2471 ER 27319 maleate
Inhibits TNF-α production
1798 Gabexate mesylate
Inhibits TNF-α production. Also antithrombotic agent
3270 GIT 27
Immunomodulator; reduces production of pro-inflammatory cytokines
1532 10Z-Hymenialdisine
Pan kinase inhibitor; blocks IL-8 production
5126 iMDK
Suppressor of MDK expression; inhibits PI 3-K signaling
3429 4-IPP
Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate
4288 ISO 1
Macrophage migration inhibitory factor (MIF) inhibitor
5185 JTE 607 dihydrochloride
Cytokine release inhibitor; anti-inflammatory
6305 Lenalidomide
TNF-α inhibitor; inhibits angiogenesis; also cereblon binder
4656 (D)-(+)-Neopterin
Stimulated by IFN-γ; marker of immune activation
1093 Pirfenidone
Antifibrotic agent; regulates cytokine levels in vivo
6302 Pomalidomide
TNFα inhibitor; also cereblon ubiquitination inhibitor and antiangiogenic
4963 SC 144 hydrochloride
gp130 inhibitor; blocks cytokine-triggered gp130 signaling
2008 SKF 86002 dihydrochloride
Inhibits human monocyte IL-1 and TNF-α production; p38 MAP kinase inhibitor
3543 Suplatast tosylate
Th2 cytokine synthesis inhibitor; antiasthmatic
0652 Thalidomide
TNF-α synthesis inhibitor; also binds cereblon

Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases.

Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems.

Cytokines can be classified into two groups: pro- and anti-inflammatory. Proinflammatory cytokines, including IFNγ, IL-1, IL-6 and TNF-α, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Literature for Cytokines

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Cytokine Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Interleukins
Il-1α Human IL1A NM_000575 P01583
Mouse Il1a NM_010554 P01582
Rat Il1a NM_017019 P16598
IL-1β Human IL1B NM_000576 P01584
Mouse Il1b NM_008361 P10749
Rat Il1b NM_031512 Q5BKB0
IL-1δ Human IL1F5 NM_173170 Q9UBH0
Mouse Il1f5 NM_019451 Q62470
Rat Il1f5 NM_001107814 XP_231101
IL-1ε Human IL1F6 NM_014440 Q9UHA7
Mouse Il1f6 NM_019450 Q9JLA2
Rat Il1f6 NM_001106554 XP_231099
IL-1ζ Human IL1F7 NM_014439 Q9NZH6
IL-1η Human IL1F8 NM_014438 Q9NZH7
Mouse Il1f8 NM_027163 Q9D6Z6
Rat Il1f8 NM_001108570 XP_342378
IL-1, family member 9 Human IL1F9 NM_019618 Q9NZH8
Mouse Il1f9 NM_153511 Q8R460
Rat Il1f9 NM_001113790 XP_575079
IL-1θ Human IL1F10 NM_173161 Q8WWZ1
Mouse Il1f10 NM_153077 Q8R459
Rat Il1f10 NM_001108571 XP_342379
IL-2 Human IL2 NM_000586 P60568
Mouse Il2 NM_008366 P04351
Rat Il2 NM_053836 P17108
IL-3 Human IL3 NM_000588 P08700
Mouse Il3 NM_010556 P01586
Rat Il3 NM_031513 P04823
IL-4 Human IL4 NM_000589 P05112
Mouse Il4 NM_021283 P07750
Rat Il4 NM_201270 P20096
IL-5 Human IL5 NM_000879 P05113
Mouse Il5 NM_010558 P04401
Rat Il5 NM_021834 Q08125
IL-6 Human IL6 NM_000600 P05231
Mouse Il6 NM_031168 P08505
Rat Il6 NM_012589 P20607
IL-7 Human IL7 NM_000880 P13232
Mouse Il7 NM_008371 P10168
Rat Il7 NM_013110 P56478
IL-8 Human IL8 NM_000584 P10145
IL-9 Human IL9 NM_000590 P15248
Mouse Il9 NM_008373 P15247
Rat Il9 NM_001105747 XP_341488
IL-10 Human IL10 NM_000572 P22301
Mouse Il10 NM_010548 P18893
Rat Il10 NM_012854 P29456
IL-11 Human IL11 NM_000641 P20809
Mouse Il11 NM_008350 P47873
Rat Il11 NM_133519 Q99MF5
IL-12A Human IL12A NM_000882 P29459
Mouse Il12a NM_008351 P43431
Rat Il12a NM_053390 Q9R103
IL-12B Human IL12B NM_002187 P29460
Mouse Il12b NM_008352 P43432
Rat Il12b NM_022611 Q62712
IL-13 Human IL13 NM_002188 P35225
Mouse Il13 NM_008355 P20109
Rat Il13 NM_053828 P42203
IL-15 Human IL15 NM_000585 P40933
Mouse Il15 NM_008357 P48346
Rat Il15 NM_013129 P97604
IL-16 Human IL16 NM_172217 Q14005
Mouse Il16 NM_010551 O54824
Rat Il16 NM_001105749 XP_218851
IL-17A Human IL17A NM_002190 Q16552
Mouse Il17a NM_010552 Q62386
Rat Il17a L13839 Q61453
IL-17B Human IL17B NM_014443 Q9UHF5
Mouse Il17b NM_019508 Q9QXT6
Rat Il17b XM_341621 Q9EQI7
IL-17C Human IL17C NM_013278 Q9P0M4
Mouse Il17c NM_145834 NP_665833
Rat Il17c XM_001078615 XP_001078615
IL-17D Human IL17D NM_138284 Q8TAD2
Mouse Il17d NM_145837 NP_665836
Rat Il17d XM_001079675 XP_001079675
IL-17F Human IL17F NM_052872 Q96PD4
Mouse Il17f NM_145856 NP_665855
Rat Il17f NM_001015011 Q5BJ95
IL-18 Human IL18 NM_001562 Q14116
Mouse Il18 NM_008360 P70380
Rat Il18 NM_019165 P97636
IL-19 Human IL19 NM_153758 Q9UHD0
Mouse Il19 NM_001009940 Q8CJ70
Rat Il19 XM_001060482 XP_001060482
IL-20 Human IL20 NM_018724 Q9NYY1
Mouse Il20 NM_021380 Q9JKV9
Rat Il20 NM_001143881 XP_001060362
IL-21 Human IL21 NM_021803 Q9HBE4
Mouse Il21 NM_021782 Q9ES17
Rat Il21 NM_001108943 XP_345202
IL-22 Human IL22 NM_020525 Q9GZX6
Mouse Il22 NM_016971 Q9JJY9
IL-23A Human IL23A NM_016584 Q9NPF7
Mouse Il23a NM_031252 Q9EQ14
Rat Il23a NM_130410 Q91Z84
IL-24 Human IL24 NM_006850 Q13007
Mouse Il24 NM_053095 Q925S4
Rat Il24 NM_133311 Q9JI24
IL-25 Human IL25 NM_172314 Q9H293
Mouse Il25 NM_080729 NP_542767
Rat Il25 XM_577423 XP_577423
IL-26 Human IL26 NM_018402 Q9NPH9
IL-27 Human IL27 NM_145659 Q8NEV9
Mouse Il27 NM_145636 Q8K3I6
Rat Il27 XM_344962 XP_344963
IL-28A Human IL28A NM_172138 Q8IZJ0
Mouse Il28a NM_001024673 Q4VK74
IL-28B Human IL28B NM_172139 Q8IZI9
Mouse Il28b NM_177396 Q8CGK6
IL-29 Human IL29 NM_172140 Q8IU54
IL-30 Human IL31 NM_001014336 Q6EBC2
Mouse Il31 AK005939 Q6EAL8
IL-32 Human IL32 NM_004221 P24001
IL-33 Human IL33 NM_033439 O95760
Mouse Il33 NM_133775 Q8BVZ5
Rat Il33 NM_001014166 Q66H70
IL-34 Human IL34 NM_152456 Q6ZMJ4
Mouse Il34 NM_029646 Q8R1R4
Rat Il34 NM_001025766 Q5DWV2
Interferons
IFN-α1 Human IFNA1 NM_024013 P01562
Mouse Ifna1 NM_010502 P01572
Rat Ifna1 NM_001014786 P05011
IFN-α2 Human IFNA2 NM_000605 P01563
Mouse Ifna2 NM_010503 P01573
Rat Ifna2 XM_233152 XP_233152
IFN-α4 Human IFNA4 NM_021068 P05014
Mouse Ifna4 NM_010504 P07351
Rat Ifna4 NM_001106667 XP_233145
IFN-α5 Human IFNA5 NM_002169 P01569
Mouse Ifna5 NM_010505 P07349
IFN-α6 Human IFNA6 NM_021002 P05013
Mouse Ifna6 NM_206871 P07350
IFN-α7 Human IFNA7 NM_021057 P01567
Mouse Ifna7 NM_008334 P06799
IFN-α8 Human IFNA8 NM_002170 P32881
IFN-α9 Human IFNA10 NM_002171 P01566
Mouse Ifna10 - -
IFN-α11 Mouse Ifna11 NM_008333 Q61716
Rat Ifna11 XM_233150 XP_233150
IFN-α12 Mouse Ifna12 NM_177361 Q80SS5
IFN-α13 Human IFNA13 NM_006900 P01562
Mouse Ifna13 NM_177347 Q80SU4
Rat Ifna13 XM_233147 -
IFN-α14 Human IFNA14 NM_002172 P01570
Mouse Ifna14 NM_206975 NP_996858
IFN-α16 Human IFNA16 NM_002173 P05015
IFN-α17 Human IFNA17 NM_021268 P01571
IFN-α21 Human IFNA21 NM_002175 P01568
IFN-β1 Human IFNB1 NM_002176 P01574
Mouse Ifnb1 NM_010510 P01575
Rat Ifnb1 NM_019127 P70499
IFN-γ Human IFNG NM_000619 P01579
Mouse Ifng NM_008337 P01580
Rat Ifng NM_138880 P01581
IFN-ε Human IFNE NM_176891 AY190045
Mouse Ifne NM_177348 Q80ZF2
IFN-κ Human IFNK NM_020124 Q9P0W0
Mouse Ifnk NM_199157 Q7TSL0
Rat Ifnk NM_001107925 XP_232873
IFN-ω Human IFNW1 NM_002177 P05000
IFN-ζ Mouse Ifnz NM_197889 NP_922871
Tumor Necrosis Factor
TNF-α Human TNF NM_000594 P01375
Mouse Tnf NM_013693 P06804
Rat Tnf NM_012675 P16599