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The MAPK Signaling Scientific Review is part of the range of scientific reviews and bulletins produced by Tocris and written by leading experts summarizing the most recent developments in research and available products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Aroon S. Karra and Melanie H. Cobb, University of Texas Southwestern Medical Center
Review excerpt: Mitogen-activated protein kinase (MAPK) networks are critical for the transmission of extracellular signals into appropriate intracellular responses. Prototypical MAPK activation employs a three-kinase core module consisting of a MAPK kinase kinase (MAPKKK or MAP3K) that phosphorylates and activates a MAPK kinase (MAP2K, MEK, or MKK) that in turn phosphorylates and dramatically increases the activity of one or more MAPKs.