BI 78D3

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Cat.No. 3314 - BI 78D3 | C13H9N5O5S2 | CAS No. 883065-90-5
Description: Selective, competitive JNK inhibitor
Chemical Name: 4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (4)
Pathways (1)

Biological Activity

Competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC50 = 500 nM) and prevents JNK substrate phosphorylation. Blocks JNK-dependent Con A-induced liver damage and restores insulin sensitivity in a mouse model of type II diabetes.

Compound Libraries

BI 78D3 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 379.37
Formula C13H9N5O5S2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 883065-90-5
PubChem ID 2747117
InChI Key QFRLDZGQEZCCJZ-UHFFFAOYSA-N
Smiles O=C1NN=C(SC3=NC=C([N+]([O-])=O)S3)N1C2=CC=C4C(OCCO4)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.94 100
ethanol 1.9 5

Preparing Stock Solutions

The following data is based on the product molecular weight 379.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.18 mL 26.36 mL
5 mM 0.53 mL 2.64 mL 5.27 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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References

References are publications that support the biological activity of the product.

Stebbins et al (2008) Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc.Natl.Acad.Sci.USA 105 16809

Flight (2008) Getting rid of JNK. Nat.Rev.Drug Disc. 7 975

Haas and Writer (2008) Block JNK at the dock. SCiBX 1 1


If you know of a relevant reference for BI 78D3, please let us know.

View Related Products by Product Action

View all JNK/c-Jun Inhibitors

Keywords: BI 78D3, BI 78D3 supplier, Selective, competitive, JNK, inhibitors, inhibits, MAPK, Signaling, Signalling, c-Jun, N-Terminal, Kinases, SAPKs, Stress-Activated, Protein, Mitogen-Activated, p38, BI78D3, JNK/c-jun, 3314, Tocris Bioscience

4 Citations for BI 78D3

Citations are publications that use Tocris products. Selected citations for BI 78D3 include:

Lahiri et al (2016) ERK2 phosphorylates Krüppel-like factor 8 protein at serine 48 to maintain its stability. Am J Cancer Res 6 910 PMID: 27293988

Eckle et al (2013) HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. Br J Pharmacol 11 e1001665 PMID: 24086109

Gandham et al (2013) Effects of Y27632 on keratinocyte procurement and wound healing. Redox Biol 38 782 PMID: 23675999

Jang et al (2015) Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury. PLoS Biol 6 552 PMID: 26491845


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for BI 78D3

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.