SR 3576

Pricing Availability   Qty
Description: Highly potent and selective JNK3 inhibitor
Chemical Name: 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)benzamide
Purity: ≥97% (HPLC)
Literature (1)
Pathways (1)

Biological Activity for SR 3576

SR 3576 is a highly potent and selective JNK3 inhibitor (IC50 = 7 nM); exhibits > 2800-fold selectivity over p38.

Compound Libraries for SR 3576

SR 3576 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SR 3576

M. Wt 501.53
Formula C27H27N5O5
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1164153-22-3
PubChem ID 70702008
Smiles O=C(NC3=CC(OC)=C(OC)C(OC)=C3)C1=CC=CC(N2C=C(NC(NC4=CC=CC(C)=C4)=O)C=N2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SR 3576

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 50.15 100

Preparing Stock Solutions for SR 3576

The following data is based on the product molecular weight 501.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.99 mL 9.97 mL 19.94 mL
5 mM 0.4 mL 1.99 mL 3.99 mL
10 mM 0.2 mL 1 mL 1.99 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for SR 3576

References are publications that support the biological activity of the product.

Kamenecka et al (2009) Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J Biol Chem. 284 12853 PMID: 19261605

If you know of a relevant reference for SR 3576, please let us know.

View Related Products by Product Action

View all JNK/c-Jun Inhibitors

Keywords: SR 3576, SR 3576 supplier, SR3576, c-Jun, N-terminal, kinase, 3alpha1, JNK3alpha1, highly, potent, selective, inhibitors, inhibits, JNK/c-jun, 5044, Tocris Bioscience

Citations for SR 3576

Citations are publications that use Tocris products.

Currently there are no citations for SR 3576. Do you know of a great paper that uses SR 3576 from Tocris? Please let us know.

Reviews for SR 3576

There are currently no reviews for this product. Be the first to review SR 3576 and earn rewards!

Have you used SR 3576?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for SR 3576

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.