SR 3576

Pricing Availability Delivery Time Qty
Cat.No. 5044 - SR 3576 | C27H27N5O5 | CAS No. 1164153-22-3
Description: Highly potent and selective JNK3 inhibitor
Chemical Name: 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)benzamide
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Highly potent and selective JNK3 inhibitor (IC50 = 7 nM); exhibits > 2800-fold selectivity over p38.

Compound Libraries

SR 3576 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 501.53
Formula C27H27N5O5
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1164153-22-3
PubChem ID 70702008
InChI Key MTFAYLZZDJGFGV-UHFFFAOYSA-N
Smiles O=C(NC3=CC(OC)=C(OC)C(OC)=C3)C1=CC=CC(N2C=C(NC(NC4=CC=CC(C)=C4)=O)C=N2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 501.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.99 mL 9.97 mL 19.94 mL
5 mM 0.4 mL 1.99 mL 3.99 mL
10 mM 0.2 mL 1 mL 1.99 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kamenecka et al (2009) Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J Biol Chem. 284 12853 PMID: 19261605


If you know of a relevant reference for SR 3576, please let us know.

View Related Products by Product Action

View all JNK/c-Jun Inhibitors

Keywords: SR 3576, supplier, SR3576, c-Jun, N-terminal, kinase, 3alpha1, JNK3alpha1, highly, potent, selective, inhibitors, inhibits, JNK/c-jun, JNK/c-jun, Tocris Bioscience

Citations for SR 3576

Citations are publications that use Tocris products.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for SR 3576

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

Protocols

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