c-JUN peptide

Pricing Availability   Qty
Description: Peptide inhibitor of JNK/c-Jun interaction
Purity: ≥95% (HPLC)
Citations (2)
Literature (1)
Pathways (1)

Biological Activity for c-JUN peptide

c-JUN peptide is a peptide comprising residues 33 - 57 of the JNK binding (δ) domain of human c-Jun. Disrupts JNK/c-Jun interaction leading to inhibition of serum-induced c-Jun phosphorylation, up-regulation of p21cip/waf and modulation of inflammatory gene expression. Specifically induces apoptosis in HeLa tumor cells.

Technical Data for c-JUN peptide

M. Wt 2743.55
Formula C121H210N36O34S
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 610273-01-3
PubChem ID 90488732
Smiles [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for c-JUN peptide

Solubility Soluble to 1 mg/ml in water

Product Datasheets for c-JUN peptide

Certificate of Analysis / Product Datasheet
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References for c-JUN peptide

References are publications that support the biological activity of the product.

Holzberg et al (2003) Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN d domain induces apoptosis and affects a distinct set of interleukin-1 induced inflammatory genes. J.Biol.Chem. 278 40213 PMID: 12832416

If you know of a relevant reference for c-JUN peptide, please let us know.

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View all JNK/c-Jun Inhibitors

Keywords: c-JUN peptide, c-JUN peptide supplier, JNK, c-Jun, interaction, inhibitors, inhibits, Peptide, N-Terminal, Kinases, Transcription, Factors, Mitogen-Activated, protein, JNK/c-jun, AP-1, 1989, Tocris Bioscience

2 Citations for c-JUN peptide

Citations are publications that use Tocris products. Selected citations for c-JUN peptide include:

Moreau et al (2015) Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy. J Urol 6 8045 PMID: 26289944

Daniels et al (2017) Inhibiting IL-1 signaling pathways to inhibit catabolic processes in disc degeneration. J Orthop Res 35 74 PMID: 27391542

Do you know of a great paper that uses c-JUN peptide from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for c-JUN peptide

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.