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Peptide comprising residues 33 - 57 of the JNK binding (δ) domain of human c-Jun. Disrupts JNK/c-Jun interaction leading to inhibition of serum-induced c-Jun phosphorylation, up-regulation of p21cip/waf and modulation of inflammatory gene expression. Specifically induces apoptosis in HeLa tumor cells.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Holzberg et al (2003) Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN d domain induces apoptosis and affects a distinct set of interleukin-1 induced inflammatory genes. J.Biol.Chem. 278 40213 PMID: 12832416
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Keywords: c-JUN peptide, c-JUN peptide supplier, JNK, c-Jun, interaction, inhibitors, inhibits, Peptide, N-Terminal, Kinases, Transcription, Factors, Mitogen-Activated, protein, JNK/c-jun, AP-1, 1989, Tocris Bioscience
2 Citations for c-JUN peptide
Citations are publications that use Tocris products. Selected citations for c-JUN peptide include:
Daniels et al (2017) Inhibiting IL-1 signaling pathways to inhibit catabolic processes in disc degeneration. J Orthop Res 35 74 PMID: 27391542
Moreau et al (2015) Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy. J Urol 6 8045 PMID: 26289944
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.