c-JUN peptide

Pricing Availability   Qty
Cat.No. 1989 - c-JUN peptide | Ile-Leu-Lys-Gln-Ser-Met-Thr-Leu-Asn-Leu-Ala-Asp-Pro-Val-Gly-Ser-Leu-Lys-Pro-His-Leu-Arg-Ala-Lys-Asn | CAS No. 610273-01-3
Description: Peptide inhibitor of JNK/c-Jun interaction
Datasheet
Citations (2)
Reviews
Literature
Pathways

Biological Activity

Peptide comprising residues 33 - 57 of the JNK binding (δ) domain of human c-Jun. Disrupts JNK/c-Jun interaction leading to inhibition of serum-induced c-Jun phosphorylation, up-regulation of p21cip/waf and modulation of inflammatory gene expression. Specifically induces apoptosis in HeLa tumor cells.

Technical Data

M. Wt 2743.55
Formula C121H210N36O34S
Sequence ILKQSMTLNLADPVGSLKPHLRAKN
Storage Desiccate at -20°C
CAS Number 610273-01-3
PubChem ID 90488732
InChI Key OVPPMIXGVMXSNS-CLIBVNCNSA-N
Smiles [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Holzberg et al (2003) Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN d domain induces apoptosis and affects a distinct set of interleukin-1 induced inflammatory genes. J.Biol.Chem. 278 40213 PMID: 12832416


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Keywords: c-JUN peptide, c-JUN peptide supplier, JNK, c-Jun, interaction, inhibitors, inhibits, Peptide, N-Terminal, Kinases, Transcription, Factors, Mitogen-Activated, protein, JNK/c-jun, AP-1, 1989, Tocris Bioscience

2 Citations for c-JUN peptide

Citations are publications that use Tocris products. Selected citations for c-JUN peptide include:

Daniels et al (2017) Inhibiting IL-1 signaling pathways to inhibit catabolic processes in disc degeneration. J Orthop Res 35 74 PMID: 27391542

Moreau et al (2015) Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy. J Urol 6 8045 PMID: 26289944


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Pathways for c-JUN peptide

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.