Adrenergic α2 Receptors

Adrenergic α2 receptors (α2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes α1A, α1B, α1D, β1, β2 and β3. Adrenergic α2 receptors are divided into three subtypes in humans: α2A, α2B and α2C.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
2759 B-HT 920
α2 agonist. Also D2 agonist and 5-HT3 antagonist
2758 B-HT 933 dihydrochloride
Selective α2 agonist
0690 Clonidine hydrochloride
α2 agonist. Also I1 ligand
2749 Dexmedetomidine hydrochloride
Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)
0885 Guanabenz acetate
α2 agonist. Also I2 selective ligand
1030 Guanfacine hydrochloride
α2A agonist
5160 Medetomidine hydrochloride
Potent, highly selective α2 agonist
2282 Moxonidine hydrochloride
α2 agonist. Also I1 agonist
2242 Octopamine hydrochloride
Invertebrate biogenic amine: activates α2A and β3 adrenoceptors
1142 Oxymetazoline hydrochloride
α2A partial agonist
0790 Rilmenidine hemifumarate
α2 agonist. Also I1 ligand
3935 RWJ 52353
α2D agonist
2638 ST 91
α2 agonist, putative α2C agonist
5021 TC-G 1000
Potent and selective α2D agonist
3609 Tizanidine hydrochloride
α2 agonist
0425 UK 14,304
α2 agonist
2466 UK 14,304 tartrate
α2 agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)

Antagonists

Cat No Product Name / Activity
2341 A 80426 mesylate
High affinity α2 antagonist. Also 5-HT uptake inhibitor
0928 ARC 239 dihydrochloride
α2B antagonist
2937 Atipamezole hydrochloride
Selective α2 antagonist
1133 BRL 44408 maleate
Selective α2A antagonist
0792 Efaroxan hydrochloride
α2 antagonist and I1, I3 ligand
0793 Idazoxan hydrochloride
α2 antagonist. Also I2 ligand
0986 Imiloxan hydrochloride
Highly selective α2B antagonist
2666 JP 1302 dihydrochloride
Potent and selective α2C antagonist
2018 Mirtazapine
α2-antagonist. Also potent 5-HT2, 5-HT3 and H1 antagonist. Antidepressant
0623 Prazosin hydrochloride
α2B and α1 antagonist. MT3 antagonist
0891 Rauwolscine hydrochloride
α2 antagonist
0987 RS 79948 hydrochloride
Potent, selective α2 antagonist
1324 RX 821002 hydrochloride
Potent, selective α2D antagonist
4508 S 32212 hydrochloride
α2 antagonist; 5-HT2C inverse agonist
3866 SKF 86466 hydrochloride
Potent and selective α2 antagonist
0631 Spiroxatrine
Potent α2C antagonist
1127 Yohimbine hydrochloride
Selective α2 antagonist

Ligand-sets

Cat No Product Name / Activity
1872 α2-Adrenoceptor Tocriset™
Selection of 5 α2-adrenoceptor ligands (Cat. Nos. 1030, 0425, 0928, 1133 and 0891)
1875 Mixed Adrenergic Tocriset™
Selection of 5 mixed adrenoceptor ligands (Cat. Nos. 0888, 0425, 1747, 0623 and 0952)

Ligands

Cat No Product Name / Activity
0842 Agmatine sulfate
α2 ligand. Also imidazoline ligand

Adrenergic α2 receptors (α2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes α1A, α1B, α1D, β1, β2 and β3. Adrenergic α2 receptors are divided into three subtypes: α2A, α2B and α2C, which are widely distributed in both the CNS and periphery. α2-adrenoceptors play a role in the modulation of neurotransmission, smooth muscle contraction and thermoregulation. A fourth pharmacological subtype, α2D, has been identified in the rat which is thought to be a species ortholog of the human α2A subtype.

External sources of pharmacological information for Adrenergic α2 Receptors :

Literature for Adrenergic α2 Receptors

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Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
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GPCR

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A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
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  • Frizzled Receptors
  • GPCR Signaling
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Cardiovascular Poster

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Depression

Depression Poster

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Pain

Pain Poster

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Parkinson's

Parkinson's Poster

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Adrenergic α2 Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
α2A Human ADRA2A NM_000681 P08913
Mouse Adra2a NM_007417 Q01338
Rat Adra2a NM_012739 P22909
α2B Human ADRA2B NM_000682 P18089
Mouse Adra2b NM_009633 P30545
Rat Adra2b NM_138505 P19328
α2C Human ADRA2C NM_000683 P18825
Mouse Adra2c NM_007418 Q01337
Rat Adra2c NM_138506 P22086