Adrenergic α2 Receptors

Adrenergic α2 receptors (α2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes α1A, α1B, α1D, β1, β2 and β3. Adrenergic α2 receptors are divided into three subtypes in humans: α2A, α2B and α2C.

Literature (6)
Gene Data

Adrenergic α2 Receptor Agonists

Cat. No. Product Name / Activity
2758 B-HT 933 dihydrochloride
Selective α2 agonist
0690 Clonidine hydrochloride
α2 agonist. Also I1 ligand
2749 Dexmedetomidine hydrochloride
Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)
0885 Guanabenz acetate
α2 agonist. Also I2 selective ligand
1030 Guanfacine hydrochloride
α2A agonist
5160 Medetomidine hydrochloride
Potent and highly selective α2 agonist
0790 Rilmenidine hemifumarate
I1 ligand. Also α2 agonist.
3609 Tizanidine hydrochloride
α2 agonist
0425 UK 14,304
α2 agonist
2466 UK 14,304 tartrate
α2 agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)

Adrenergic α2 Receptor Antagonists

Cat. No. Product Name / Activity
0928 ARC 239 dihydrochloride
α2B antagonist
2937 Atipamezole hydrochloride
Selective α2 antagonist
1133 BRL 44408 maleate
Selective α2A antagonist
0986 Imiloxan hydrochloride
Highly selective α2B antagonist
2666 JP 1302 dihydrochloride
Potent and selective α2C antagonist
2018 Mirtazapine
α2 antagonist; also potent 5-HT2, 5-HT3 and H1 antagonist; antidepressant
0623 Prazosin hydrochloride
α2B and α1 antagonist; also MT3 antagonist
0891 Rauwolscine hydrochloride
α2 antagonist
0987 RS 79948 hydrochloride
Potent and selective α2 antagonist
1324 RX 821002 hydrochloride
Potent, selective α2D antagonist
4508 S 32212 hydrochloride
α2-adrenoceptor antagonist; 5-HT2C inverse agonist
3866 SKF 86466 hydrochloride
Potent and selective α2 antagonist
0631 Spiroxatrine
Potent α2C antagonist
1127 Yohimbine hydrochloride
Selective α2 antagonist

Adrenergic α2 receptors (α2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes α1A, α1B, α1D, β1, β2 and β3. Adrenergic α2 receptors are divided into three subtypes: α2A, α2B and α2C, which are widely distributed in both the CNS and periphery. α2-adrenoceptors play a role in the modulation of neurotransmission, smooth muscle contraction and thermoregulation. A fourth pharmacological subtype, α2D, has been identified in the rat which is thought to be a species ortholog of the human α2A subtype.

External sources of pharmacological information for Adrenergic α2 Receptors :

Literature for Adrenergic α2 Receptors

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Adrenergic α2 Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
α2A Human ADRA2A NM_000681 P08913
Mouse Adra2a NM_007417 Q01338
Rat Adra2a NM_012739 P22909
α2B Human ADRA2B NM_000682 P18089
Mouse Adra2b NM_009633 P30545
Rat Adra2b NM_138505 P19328
α2C Human ADRA2C NM_000683 P18825
Mouse Adra2c NM_007418 Q01337
Rat Adra2c NM_138506 P22086