Adrenergic β3 Receptors

The adrenergic β3 receptor (β3-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes α1A, α1B, α1D, α2A, α2B, α2C, β1 and β2. They are located primarily in the small intestine, adipose tissue and vascular endothelium.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
0948 BRL 37344, sodium salt
β3 agonist
1134 CGP 12177 hydrochloride
β3 partial agonist. β12 antagonist.
1499 CL 316243 disodium salt
Highly selective β3 agonist
0929 ICI 215,001 hydrochloride
β3 agonist
2197 L-755,507
Very potent and selective β3 partial agonist
2242 Octopamine hydrochloride
Invertebrate biogenic amine: activates β3 adrenoceptors
0994 Pindolol
β3 partial agonist
1060 (S)-(-)-Pindolol
β3 partial agonist. More active enantiomer of pindolol (Cat. No. 0994)
3986 SR 58611A hydrochloride
β3 agonist; displays anxiolytic and antidepressant effects
2154 ZD 2079
β3-adrenoceptor agonist
0930 ZD 7114 hydrochloride
β3 agonist

Antagonists

Cat No Product Name / Activity
2760 L-748,337
Selective β3 antagonist
1511 SR 59230A hydrochloride
Potent and selective β3 antagonist

Ligand-sets

Cat No Product Name / Activity
1873 β-Adrenoceptor Agonist Tocriset™
Selection of 3 β-adrenoceptor agonists (Cat. Nos. 0948, 1747 and 1660)
1874 β-Adrenoceptor Antagonist Tocriset™
Selection of 3 β-adrenoceptor antagonists (Cat. Nos. 1024, 0821 and 1511)

The adrenergic β3 receptor (β3-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes α1A, α1B, α1D, α2A, α2B, α2C, β1 and β2. They are located primarily in the small intestine, adipose tissue and vascular endothelium where they are involved in lipolysis, glucose uptake, cardio-inhibition and relaxation of colon, esophagus and bladder. The human β3 receptor gene has been localized to chromosome 8 (8p12-8p11.1).

External sources of pharmacological information for Adrenergic β3 Receptors :

Literature for Adrenergic β3 Receptors

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Adrenergic β3 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human ADRB3 NM_000025 P13945
Mouse Adrb3 NM_013462 P25962
Rat Adrb3 NM_013108 P26255