Pricing Availability   Qty
Description: Potent 5-HT2 antagonist; also 5-HT3, H1 and α2 antagonist; antidepressant
Alternative Names: Org 3770,6-Azamianserin
Chemical Name: 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
Purity: ≥99% (HPLC)
Citations (2)
Literature (1)

Biological Activity for Mirtazapine

Mirtazapine is an antidepressant agent; potent 5-HT2, 5-HT3 and histamine H1 receptor antagonist and moderately potent α2-adrenoceptor antagonist (pKi values are 8.05, ~ 8.1, 9.3 and 6.95 respectively). Enhances noradrenaline (NA) release in rat brain via inhibition of α2-adrenergic autoreceptors and displays only weak affinity for monoamine transporters (pKi values are 5.6, < 5 and < 5.1 for inhibition of NA, dopamine and 5-HT uptake respectively). Increases hippocampal NA and 5-HT levels in rats following systemic administration in vivo.

Compound Libraries for Mirtazapine

Mirtazapine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Mirtazapine

M. Wt 265.36
Formula C17H19N3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 85650-52-8
PubChem ID 4205
Smiles CN1CCN2C(C1)C1=CC=CC=C1CC1=C2N=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Mirtazapine

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 13.27 50
DMSO 5.31 20

Preparing Stock Solutions for Mirtazapine

The following data is based on the product molecular weight 265.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.54 mL 37.68 mL 75.37 mL
2.5 mM 1.51 mL 7.54 mL 15.07 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
25 mM 0.15 mL 0.75 mL 1.51 mL

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Product Datasheets for Mirtazapine

Certificate of Analysis / Product Datasheet
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References for Mirtazapine

References are publications that support the biological activity of the product.

de Boer et al (1988) Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, ORG 3770 and its enantiomers. Neuropharmacology 27 399 PMID: 3419539

Kooyman et al (1994) Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells. Neuropharmacology 33 501 PMID: 7984289

de Boer et al (1996) Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazepine, mianserin and idazoxan. J.Pharmacol.Exp.Ther. 277 852 PMID: 8627567

If you know of a relevant reference for Mirtazapine, please let us know.

View Related Products by Product Action

View all Non-selective 5-HT2 Antagonists

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2 Citations for Mirtazapine

Citations are publications that use Tocris products. Selected citations for Mirtazapine include:

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Cancer Res 7 2336 PMID: 26114334

Midkiff et al (2011) Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One 6 e25395 PMID: 21966518

Do you know of a great paper that uses Mirtazapine from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.