Mirtazapine

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Cat.No. 2018 - Mirtazapine | C17H19N3 | CAS No. 85650-52-8
Description: Potent 5-HT2 antagonist; also 5-HT3, H1 and α2 antagonist; antidepressant
Alternative Names: Org 3770, 6-Azamianserin
Chemical Name: 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Antidepressant agent; potent 5-HT2, 5-HT3 and histamine H1 receptor antagonist and moderately potent α2-adrenoceptor antagonist (pKi values are 8.05, ~ 8.1, 9.3 and 6.95 respectively). Enhances noradrenalin (NA) release in rat brain via inhibition of α2-adrenergic autoreceptors and displays only weak affinity for monoamine transporters (pKi values are 5.6, < 5 and < 5.1 for inhibition of NA, dopamine and 5-HT uptake respectively). Increases hippocampal NA and 5-HT levels in rats following systemic administration in vivo.

Compound Libraries

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Technical Data

M. Wt 265.36
Formula C17H19N3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 85650-52-8
PubChem ID 4205
InChI Key RONZAEMNMFQXRA-UHFFFAOYSA-N
Smiles CN1CCN2C(C1)C1=CC=CC=C1CC1=C2N=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 13.27 50
DMSO 5.31 20

Preparing Stock Solutions

The following data is based on the product molecular weight 265.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.54 mL 37.68 mL 75.37 mL
2.5 mM 1.51 mL 7.54 mL 15.07 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
25 mM 0.15 mL 0.75 mL 1.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

de Boer et al (1988) Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, ORG 3770 and its enantiomers. Neuropharmacology 27 399 PMID: 3419539

Kooyman et al (1994) Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells. Neuropharmacology 33 501 PMID: 7984289

de Boer et al (1996) Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazepine, mianserin and idazoxan. J.Pharmacol.Exp.Ther. 277 852 PMID: 8627567


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2 Citations for Mirtazapine

Citations are publications that use Tocris products. Selected citations for Mirtazapine include:

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Cancer Res 7 2336 PMID: 26114334

Midkiff et al (2011) Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One 6 e25395 PMID: 21966518


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Literature in this Area

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GPCR

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.