B-HT 933 dihydrochloride

Pricing Availability   Qty
Description: Selective α2 agonist
Alternative Names: Azepexole
Chemical Name: 6-Ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for B-HT 933 dihydrochloride

B-HT 933 dihydrochloride is a selective α2-adrenoceptor agonist. Exhibits greater than 300-fold selectivity for the α2-adrenoceptor over the α1-adrenoceptor.

Compound Libraries for B-HT 933 dihydrochloride

B-HT 933 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for B-HT 933 dihydrochloride

M. Wt 254.16
Formula C9H15N3O.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 36067-72-8
PubChem ID 169743
Smiles CCN1CCC(OC(N)=N2)=C2CC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for B-HT 933 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 25.42 100
DMSO 12.71 50

Preparing Stock Solutions for B-HT 933 dihydrochloride

The following data is based on the product molecular weight 254.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.67 mL 39.35 mL
5 mM 0.79 mL 3.93 mL 7.87 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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Product Datasheets for B-HT 933 dihydrochloride

Certificate of Analysis / Product Datasheet
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References for B-HT 933 dihydrochloride

References are publications that support the biological activity of the product.

Bill et al (1989) The thermogenic actions of α2-adrenoceptor agonists in reserpinized mice are mediated via a central postsynaptic α2-adrenoceptor mechanism. Br.J.Pharmacol. 96 133 PMID: 2564288

Parkinson and Hughes (1995) The mechanism of action of α2-adrenoceptors in human isolated subcutaneous resistance arteries. Br.J.Pharmacol. 115 1463 PMID: 8564206

Kobinger and Pichler (1977) Pharmacological characterization of B-HT 933 (2-amino-6-ethyl-4,5,7,8-tetrahydro-6H-oxazolo-[5,4-d]-azepindihydrochloride) as a hypotensive agent of the "clonidine-type". Naunyn-Schmied.Arch.Pharmacol. 300 39 PMID: 22821

If you know of a relevant reference for B-HT 933 dihydrochloride, please let us know.

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1 Citation for B-HT 933 dihydrochloride

Citations are publications that use Tocris products. Selected citations for B-HT 933 dihydrochloride include:

Hamby et al (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. Toxins (Basel) 32 14489 PMID: 23077035

Do you know of a great paper that uses B-HT 933 dihydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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