Tizanidine hydrochloride

Pricing Availability   Qty
Description: α2 agonist
Chemical Name: 5-(Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for Tizanidine hydrochloride

Tizanidine hydrochloride is an α2-adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC50 = 48 nM). Also binds to imidazoline receptor.

Compound Libraries for Tizanidine hydrochloride

Tizanidine hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Tizanidine hydrochloride

M. Wt 290.17
Formula C9H8ClN5S.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 64461-82-1
PubChem ID 114869
Smiles ClC2=C(NC3=NCCN3)C1=NSN=C1C=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Tizanidine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 29.02 100
DMSO 29.02 100

Preparing Stock Solutions for Tizanidine hydrochloride

The following data is based on the product molecular weight 290.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.45 mL 17.23 mL 34.46 mL
5 mM 0.69 mL 3.45 mL 6.89 mL
10 mM 0.34 mL 1.72 mL 3.45 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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Product Datasheets for Tizanidine hydrochloride

References for Tizanidine hydrochloride

References are publications that support the biological activity of the product.

Asano et al (2000) Antinociception by epidural and systemic α2-adrenoceptor agonists and their binding affinity in rat spinal cord and brain. Anesth.Analg. 90 400 PMID: 10648329

Piletz et al (2000) Autoradiographic comparison of [3H]-Clonidine binding to non-adrenergic sites and α2-adrenergic receptors in human brain. Neuropsychopharmacology 23 697 PMID: 11063925

If you know of a relevant reference for Tizanidine hydrochloride, please let us know.

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1 Citation for Tizanidine hydrochloride

Citations are publications that use Tocris products. Selected citations for Tizanidine hydrochloride include:

Thomas C et al (2019) Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell 179 498-513.e22 PMID: 31585084

Do you know of a great paper that uses Tizanidine hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.