Tizanidine hydrochloride

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Cat.No. 3609 - Tizanidine hydrochloride | C9H8ClN5S.HCl | CAS No. 64461-82-1
Description: α2 agonist
Chemical Name: 5-(Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

α2-adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC50 = 48 nM). Also binds to imidazoline receptor.

Compound Libraries

Tizanidine hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 290.17
Formula C9H8ClN5S.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 64461-82-1
PubChem ID 114869
InChI Key ZWUKMNZJRDGCTQ-UHFFFAOYSA-N
Smiles ClC2=C(NC3=NCCN3)C1=NSN=C1C=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.02 100
water 29.02 100

Preparing Stock Solutions

The following data is based on the product molecular weight 290.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.45 mL 17.23 mL 34.46 mL
5 mM 0.69 mL 3.45 mL 6.89 mL
10 mM 0.34 mL 1.72 mL 3.45 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Asano et al (2000) Antinociception by epidural and systemic α2-adrenoceptor agonists and their binding affinity in rat spinal cord and brain. Anesth.Analg. 90 400 PMID: 10648329

Piletz et al (2000) Autoradiographic comparison of [3H]-Clonidine binding to non-adrenergic sites and α2-adrenergic receptors in human brain. Neuropsychopharmacology 23 697 PMID: 11063925


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Keywords: α2-Adrenergic alpha2-Adrenergic a2-adrenergic α2-adrenoceptor alpha2-adrenoceptors a2-adrenoceptors agonists Receptors Adrenergic Alpha-2 Receptors

Citations for Tizanidine hydrochloride

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Literature in this Area

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Pathways for Tizanidine hydrochloride

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