α2-adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC50 = 48 nM). Also binds to imidazoline receptor.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 290.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.45 mL||17.23 mL||34.46 mL|
|5 mM||0.69 mL||3.45 mL||6.89 mL|
|10 mM||0.34 mL||1.72 mL||3.45 mL|
|50 mM||0.07 mL||0.34 mL||0.69 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Asano et al (2000) Antinociception by epidural and systemic α2-adrenoceptor agonists and their binding affinity in rat spinal cord and brain. Anesth.Analg. 90 400 PMID: 10648329
Piletz et al (2000) Autoradiographic comparison of [3H]-Clonidine binding to non-adrenergic sites and α2-adrenergic receptors in human brain. Neuropsychopharmacology 23 697 PMID: 11063925
If you know of a relevant reference for Tizanidine hydrochloride, please let us know.
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Keywords: α2-Adrenergic alpha2-Adrenergic a2-adrenergic α2-adrenoceptor alpha2-adrenoceptors a2-adrenoceptors agonists Receptors Adrenergic Alpha-2 Receptors
Citations for Tizanidine hydrochloride
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