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Biological Activity for Tizanidine hydrochloride
Tizanidine hydrochloride is an α2-adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC50 = 48 nM). Also binds to imidazoline receptor.
Compound Libraries for Tizanidine hydrochloride
Technical Data for Tizanidine hydrochloride
|Desiccate at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Tizanidine hydrochloride
|Max Conc. mg/mL
|Max Conc. mM
Preparing Stock Solutions for Tizanidine hydrochloride
The following data is based on the product molecular weight 290.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass
Product Datasheets for Tizanidine hydrochloride
References for Tizanidine hydrochloride
References are publications that support the biological activity of the product.
Asano et al (2000) Antinociception by epidural and systemic α2-adrenoceptor agonists and their binding affinity in rat spinal cord and brain. Anesth.Analg. 90 400 PMID: 10648329
Piletz et al (2000) Autoradiographic comparison of [3H]-Clonidine binding to non-adrenergic sites and α2-adrenergic receptors in human brain. Neuropsychopharmacology 23 697 PMID: 11063925
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1 Citation for Tizanidine hydrochloride
Citations are publications that use Tocris products. Selected citations for Tizanidine hydrochloride include:
Thomas C et al (2019) Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell 179 498-513.e22 PMID: 31585084
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.