Adrenergic α1 Receptors
Adrenergic α1 receptors (α1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes α2A, α2B, α2C, β1, β2 and β3. The adrenergic α1 receptors are further divided into three subtypes: α1A, α1B and α1D receptors.
Adrenergic α1 Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 1052 | A 61603 hydrobromide |
| α1A agonist | |
| 0888 | Cirazoline hydrochloride |
| Selective α1 agonist | |
| 2838 | (R)-(-)-Phenylephrine hydrochloride |
| α1 agonist | |
Adrenergic α1 Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 2685 | Carvedilol |
| Potent α1 antagonist; also potent and non-selective β antagonist | |
| 2964 | Doxazosin mesylate |
| α1 antagonist | |
| 0535 | HEAT hydrochloride |
| Highly selective α1 antagonist | |
| 0545 | Ifenprodil hemitartrate |
| α1 antagonist. Also NMDA antagonist and σ ligand | |
| 0597 | Naftopidil hydrochloride |
| α1 antagonist | |
| 0623 | Prazosin hydrochloride |
| α1 and α2B antagonist; also MT3 antagonist | |
| 1325 | RS 100329 hydrochloride |
| Potent, subtype-selective α1A antagonist | |
| 0985 | RS 17053 hydrochloride |
| α1A antagonist | |
| 6663 | Silodosin |
| Selective α1A antagonist | |
| 3050 | Tamsulosin hydrochloride |
| Selective α1A antagonist | |
| 1506 | Terazosin hydrochloride |
| α1 and α2B antagonist (α1 > α2B). Orally active | |
| 6336 | Trazodone hydrochloride |
| 5-HT2A and α1 adrenoceptor antagonist; also enhances neural differentiation; antidepressant and neuroprotectant | |
Degraders |
|
| Cat. No. | Product Name / Activity |
| 7278 | α1A-AR Degrader 9c |
| Selective α1A adrenergic receptor Degrader (PROTAC®) | |
Other |
|
| Cat. No. | Product Name / Activity |
| 7952 | CELT-133 New |
| Selective hα1A adrenergic receptor fluorescent antagonist | |
Adrenergic α1 receptors (α1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes α2A, α2B, α2C, β1, β2 and β3. The adrenergic α1 receptors are further divided into three subtypes: α1A, α1B and α1D receptors. α1-adrenoceptors are widely distributed in both the CNS and periphery where they play a major role in smooth muscle contraction. A fourth α1 receptor subtype has been postulated and is designated as α1L based on its low affinity for prazosin. It has been suggested that this subtype may represent a different conformational state of the α1A subtype.
External sources of pharmacological information for Adrenergic α1 Receptors :
Literature for Adrenergic α1 Receptors
Tocris offers the following scientific literature for Adrenergic α1 Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Adrenergic α1 Receptor Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| α1A | Human | ADRA1A | NM_033303 | P35348 |
| Mouse | Adra1a | NM_013461 | P97718 | |
| Rat | Adra1a | NM_017191 | P43140 | |
| α1B | Human | ADRA1B | NM_000679 | P35368 |
| Mouse | Adra1b | NM_007416 | P97717 | |
| Rat | Adra1b | NM_016991 | P15823 | |
| α1D | Human | ADRA1D | NM_000678 | P25100 |
| Mouse | Adra1d | NM_013460 | P97714 | |
| Rat | Adra1d | NM_024483 | P23944 |
Written by P. Skolnich et al
Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder.
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