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Adrenergic α1 Receptors

Adrenergic α1 receptors (α1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes α2A, α2B, α2C, β1, β2 and β3. The adrenergic α1 receptors are further divided into three subtypes: α1A, α1B and α1D receptors.

Products
Background
Literature (4)
Gene Data

Adrenergic α1 Receptor Agonists
Cat. No. Product Name / Activity
1052 A 61603 hydrobromide
α1A agonist
0888 Cirazoline hydrochloride
Selective α1 agonist
2838 (R)-(-)-Phenylephrine hydrochloride
α1 agonist

Adrenergic α1 Receptor Antagonists
Cat. No. Product Name / Activity
2685 Carvedilol
Potent α1 antagonist; also potent and non-selective β antagonist
2964 Doxazosin mesylate
α1 antagonist
0535 HEAT hydrochloride
Highly selective α1 antagonist
0545 Ifenprodil hemitartrate
α1 antagonist. Also NMDA antagonist and σ ligand
0597 Naftopidil hydrochloride
α1 antagonist
0623 Prazosin hydrochloride
α1 and α2B antagonist; also MT3 antagonist
1325 RS 100329 hydrochloride
Potent, subtype-selective α1A antagonist
0985 RS 17053 hydrochloride
α1A antagonist
6663 Silodosin
Selective α1A antagonist
3050 Tamsulosin hydrochloride
Selective α1A antagonist
1506 Terazosin hydrochloride
α1 and α2B antagonist (α1 > α2B). Orally active
6336 Trazodone hydrochloride
5-HT2A and α1 adrenoceptor antagonist; also enhances neural differentiation; antidepressant and neuroprotectant

Degraders
Cat. No. Product Name / Activity
7278 α1A-AR Degrader 9c
Selective α1A adrenergic receptor Degrader (PROTAC®)

Related Targets

Adrenergic α1 receptors (α1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes α2A, α2B, α2C, β1, β2 and β3. The adrenergic α1 receptors are further divided into three subtypes: α1A, α1B and α1D receptors. α1-adrenoceptors are widely distributed in both the CNS and periphery where they play a major role in smooth muscle contraction. A fourth α1 receptor subtype has been postulated and is designated as α1L based on its low affinity for prazosin. It has been suggested that this subtype may represent a different conformational state of the α1A subtype.

External sources of pharmacological information for Adrenergic α1 Receptors :

Literature for Adrenergic α1 Receptors

Tocris offers the following scientific literature for Adrenergic α1 Receptors to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Cardiovascular Poster

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Adrenergic α1 Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
α1A Human ADRA1A NM_033303 P35348
Mouse Adra1a NM_013461 P97718
Rat Adra1a NM_017191 P43140
α1B Human ADRA1B NM_000679 P35368
Mouse Adra1b NM_007416 P97717
Rat Adra1b NM_016991 P15823
α1D Human ADRA1D NM_000678 P25100
Mouse Adra1d NM_013460 P97714
Rat Adra1d NM_024483 P23944