Adrenergic α1 receptors (α1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes α2A, α2B, α2C, β1, β2 and β3. The adrenergic α1 receptors are further divided into three subtypes: α1A, α1B and α1D receptors.
Adrenergic α1 Receptor Agonists |
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Cat. No. | Product Name / Activity |
1052 | A 61603 hydrobromide |
α1A agonist | |
0888 | Cirazoline hydrochloride |
Selective α1 agonist | |
2838 | (R)-(-)-Phenylephrine hydrochloride |
α1 agonist | |
Adrenergic α1 Receptor Antagonists |
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Cat. No. | Product Name / Activity |
2685 | Carvedilol |
Potent α1 antagonist; also potent and non-selective β antagonist | |
2964 | Doxazosin mesylate |
α1 antagonist | |
0535 | HEAT hydrochloride |
Highly selective α1 antagonist | |
0545 | Ifenprodil hemitartrate |
α1 antagonist. Also NMDA antagonist and σ ligand | |
0597 | Naftopidil hydrochloride |
α1 antagonist | |
0623 | Prazosin hydrochloride |
α1 and α2B antagonist; also MT3 antagonist | |
1325 | RS 100329 hydrochloride |
Potent, subtype-selective α1A antagonist | |
0985 | RS 17053 hydrochloride |
α1A antagonist | |
6663 | Silodosin |
Selective α1A antagonist | |
3050 | Tamsulosin hydrochloride |
Selective α1A antagonist | |
1506 | Terazosin hydrochloride |
α1 and α2B antagonist (α1 > α2B). Orally active | |
6336 | Trazodone hydrochloride |
5-HT2A and α1 adrenoceptor antagonist; also enhances neural differentiation; antidepressant and neuroprotectant | |
Degraders |
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Cat. No. | Product Name / Activity |
7278 | α1A-AR Degrader 9c |
Selective α1A adrenergic receptor Degrader (PROTAC®) |
Adrenergic α1 receptors (α1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes α2A, α2B, α2C, β1, β2 and β3. The adrenergic α1 receptors are further divided into three subtypes: α1A, α1B and α1D receptors. α1-adrenoceptors are widely distributed in both the CNS and periphery where they play a major role in smooth muscle contraction. A fourth α1 receptor subtype has been postulated and is designated as α1L based on its low affinity for prazosin. It has been suggested that this subtype may represent a different conformational state of the α1A subtype.
Tocris offers the following scientific literature for Adrenergic α1 Receptors to showcase our products. We invite you to request* your copy today!
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Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
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α1A | Human | ADRA1A | NM_033303 | P35348 |
Mouse | Adra1a | NM_013461 | P97718 | |
Rat | Adra1a | NM_017191 | P43140 | |
α1B | Human | ADRA1B | NM_000679 | P35368 |
Mouse | Adra1b | NM_007416 | P97717 | |
Rat | Adra1b | NM_016991 | P15823 | |
α1D | Human | ADRA1D | NM_000678 | P25100 |
Mouse | Adra1d | NM_013460 | P97714 | |
Rat | Adra1d | NM_024483 | P23944 |