Adrenergic β1 Receptors

The adrenergic β1 receptor (β1-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes α1A, α1B, α1D, α2A, α2B, α2C, β2 and β3. They are located primarily in the CNS, heart, coronary artery, kidney and muscle.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
0950 Xamoterol hemifumarate
β1 selective partial agonist

Antagonists

Cat No Product Name / Activity
0387 (RS)-Atenolol
β1 antagonist
0393 (S)-(-)-Atenolol
β1-antagonist. Active isomer of atenolol (Cat. No. 0387)
0906 Betaxolol hydrochloride
Selective β1 antagonist
0914 (±)-Bisoprolol hemifumarate
β1 antagonist
1024 CGP 20712 dihydrochloride
Highly potent and selective β1 antagonist
3256 Metoprolol tartrate
Selective β1 antagonist
3517 Nebivolol hydrochloride
Highly selective β1-adrenoceptor antagonist
0649 (S)-Timolol maleate
β1 antagonist

Ligand-sets

Cat No Product Name / Activity
1874 β-Adrenoceptor Antagonist Tocriset™
Selection of 3 β-adrenoceptor antagonists (Cat. Nos. 1024, 0821 and 1511)

The adrenergic β1 receptor (β1-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes α1A, α1B, α1D, α2A, α2B, α2C, β2 and β3. They are located primarily in the CNS, heart, coronary artery, kidney and muscle and are involved in cardiac stimulation, coronary vasodilation and relaxation of the colon and esophagus. The human adrenergic β1 receptor gene has been localized to chromosome 10 (10q24-q26).

External sources of pharmacological information for Adrenergic β1 Receptors :

Literature for Adrenergic β1 Receptors

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Adrenergic β1 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human ADRB1 NM_000684 P08588
Mouse Adrb1 NM_007419 P34971
Rat Adrb1 NM_012701 P18090