Imiloxan hydrochloride

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Description: Highly selective α2B antagonist
Alternative Names: RS 21361
Chemical Name: 2-(1-Ethyl-2-indazoyl)methyl-1,4-benzodioxan hydrochloride
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Imiloxan hydrochloride

Imiloxan hydrochloride is a moderately potent, but highly selective α2-adrenoceptor antagonist, the only reported selective antagonist at the α2B-adrenoceptor not having potent α1-adrenoceptor antagonist activity.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data for Imiloxan hydrochloride

M. Wt 280.75
Formula C14H16N2O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 81167-22-8
PubChem ID 172975

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Imiloxan hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 28.07 100

Preparing Stock Solutions for Imiloxan hydrochloride

The following data is based on the product molecular weight 280.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.56 mL 17.81 mL 35.62 mL
5 mM 0.71 mL 3.56 mL 7.12 mL
10 mM 0.36 mL 1.78 mL 3.56 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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Product Datasheets for Imiloxan hydrochloride

Certificate of Analysis / Product Datasheet
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References for Imiloxan hydrochloride

References are publications that support the biological activity of the product.

Michel et al (1990) Assessment of imiloxan as a selective α2B-adrenoceptor antagonist. Br.J.Pharmacol. 99 560 PMID: 1970500

Michel and Whiting (1981) 2-(2-Imidazolylmethyl)-1,4-benzodioxans, a series of selective alpha2-adrenoceptor antagonists. Br.J.Pharmacol. 74 255P

If you know of a relevant reference for Imiloxan hydrochloride, please let us know.

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Citations for Imiloxan hydrochloride

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