Guanfacine hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 1030 - Guanfacine hydrochloride | C9H9Cl2N3O.HCl | CAS No. 29110-48-3
Description: α2A agonist
Chemical Name: [(2,6-Dichlorophenyl)acetyl]guanidine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Selective α2A-adrenoceptor agonist (Kd = 31 nM). Displays 60-fold selectivity over α2B-adrenoceptors. Also available as part of the α2-Adrenoceptor Tocriset™.

Technical Data

M. Wt 282.56
Formula C9H9Cl2N3O.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 29110-48-3
PubChem ID 71401
InChI Key DGFYECXYGUIODH-UHFFFAOYSA-N
Smiles Cl.NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.26 100
water 28.26 100

Preparing Stock Solutions

The following data is based on the product molecular weight 282.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.7 mL 35.39 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Intengan and Smyth (1997) Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance. J.Pharmacol.Exp.Ther. 281 48 PMID: 9103479

Uhlen and Wikberg (1991) Delineation of rat kidney α2A- and α2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an α2A -selective compound. Eur.J.Pharmacol. 202 235 PMID: 1666366

Merck Index 12 4590 PMID:


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Keywords: α2A-adrenoceptor alpha2A-adrenoceptor a2a-adrenoceptor a2a-adrenergic α2a-adrenergic alpha2a-adrenergic agonists Receptors Adrenergic Alpha-2 Receptors

2 Citations for Guanfacine hydrochloride

Citations are publications that use Tocris products. Selected citations for Guanfacine hydrochloride include:

An et al (2014) Neuritin can normalize neural deficits of Alzheimer's disease. Cell Death Dis 5 e1523 PMID: 25393479

Hamby et al (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. Pharmacol Res Perspect 32 14489 PMID: 23077035


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Pathways for Guanfacine hydrochloride

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