Guanfacine hydrochloride

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Cat.No. 1030 - Guanfacine hydrochloride | C9H9Cl2N3O.HCl | CAS No. 29110-48-3
Description: α2A agonist
Chemical Name: [(2,6-Dichlorophenyl)acetyl]guanidine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (6)

Biological Activity

Selective α2A-adrenoceptor agonist (Kd = 31 nM). Displays 60-fold selectivity over α2B-adrenoceptors. Also available as part of the α2-Adrenoceptor Tocriset™.

Technical Data

M. Wt 282.56
Formula C9H9Cl2N3O.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 29110-48-3
PubChem ID 71401
InChI Key DGFYECXYGUIODH-UHFFFAOYSA-N
Smiles Cl.NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 28.26 100
DMSO 28.26 100

Preparing Stock Solutions

The following data is based on the product molecular weight 282.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.7 mL 35.39 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Intengan and Smyth (1997) Alpha-2a/d adrenoceptor subtype stimulation by guanf. increases osmolar clearance. J.Pharmacol.Exp.Ther. 281 48 PMID: 9103479

Uhlen and Wikberg (1991) Delineation of rat kidney α2A- and α2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanf. is an α2A -selective compound. Eur.J.Pharmacol. 202 235 PMID: 1666366

Merck Index 12 4590


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4 Citations for Guanfacine hydrochloride

Citations are publications that use Tocris products. Selected citations for Guanfacine hydrochloride include:

Shields et al (2009) alpha2A-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalis. Neuroscience 163 339 PMID: 19527774

Harris et al (2018) Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci 38 8922 PMID: 30150361

An et al (2014) Neuritin can normalize neural deficits of Alzheimer's disease. Cell Death Dis 5 e1523 PMID: 25393479

Hamby et al (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. Pharmacol Res Perspect 32 14489 PMID: 23077035


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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