Selective α2A-adrenoceptor agonist (Kd = 31 nM). Displays 60-fold selectivity over α2B-adrenoceptors. Also available as part of the α2-Adrenoceptor Tocriset™.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 282.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.54 mL||17.7 mL||35.39 mL|
|5 mM||0.71 mL||3.54 mL||7.08 mL|
|10 mM||0.35 mL||1.77 mL||3.54 mL|
|50 mM||0.07 mL||0.35 mL||0.71 mL|
References are publications that support the products' biological activity.
Intengan and Smyth (1997) Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance. J.Pharmacol.Exp.Ther. 281 48 PMID: 9103479
Uhlen and Wikberg (1991) Delineation of rat kidney α2A- and α2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an α2A -selective compound. Eur.J.Pharmacol. 202 235 PMID: 1666366
If you know of a relevant reference for Guanfacine hydrochloride, please let us know.
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Keywords: Guanfacine hydrochloride, supplier, α2A-adrenoceptor, alpha2A-adrenoceptor, a2a-adrenoceptor, a2a-adrenergic, α2a-adrenergic, alpha2a-adrenergic, agonists, Receptors, Adrenergic, Alpha-2, Receptors, Adrenergic, Alpha-2, Receptors, Tocris Bioscience
2 Citations for Guanfacine hydrochloride
Citations are publications that use Tocris products. Selected citations for Guanfacine hydrochloride include:
An et al (2014) Neuritin can normalize neural deficits of Alzheimer's disease. Cell Death Dis 5 e1523 PMID: 25393479
Hamby et al (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. Pharmacol Res Perspect 32 14489 PMID: 23077035
Do you know of a great paper that uses Guanfacine hydrochloride from Tocris? If so please let us know.
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