Dexmedetomidine hydrochloride

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Cat.No. 2749 - Dexmedetomidine hydrochloride | C13H16N2.HCl | CAS No. 145108-58-3
Description: Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)
Alternative Names: d-Medetomidine hydrochloride
Chemical Name: 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Active isomer of medetomidine (Cat.No. 5160), a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Compound Libraries

Dexmedetomidine hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 236.74
Formula C13H16N2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 145108-58-3
PubChem ID 6918081
InChI Key VPNGEIHDPSLNMU-MERQFXBCSA-N
Smiles C[C@H](C2=CN=CN2)C1=C(C)C(C)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.67 100
ethanol 5.92 25
water 23.67 100

Preparing Stock Solutions

The following data is based on the product molecular weight 236.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.22 mL 21.12 mL 42.24 mL
5 mM 0.84 mL 4.22 mL 8.45 mL
10 mM 0.42 mL 2.11 mL 4.22 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Virtanen et al (1988) Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist. Eur.J.Pharmacol. 150 9 PMID: 2900154

Fisher et al (1991) Antinociceptive properties of intrathecal dexmedetomidine in rats. Eur.J.Pharmacol. 192 221 PMID: 1674472

Scheinin et al (1989) Medetomidine - a novel α2-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 13 635 PMID:


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3 Citations for Dexmedetomidine hydrochloride

Citations are publications that use Tocris products. Selected citations for Dexmedetomidine hydrochloride include:

Yuki et al (2011) Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function. Anesth Analg 112 830 PMID: 21385989

Garrity et al (2015) Dexmedetomidine-induced sedation does not mimic the neurobehavioral phenotypes of sleep in Sprague Dawley rat. Invest Ophthalmol Vis Sci 38 73 PMID: 25325438

McAlvin et al (2015) Corneal Anesthesia With Site 1 Sodium Channel Blockers and Dexmedetomidine. J Inflamm (Lond) 56 3820 PMID: 26066750


Do you know of a great paper that uses Dexmedetomidine hydrochloride from Tocris? If so please let us know.

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Pathways for Dexmedetomidine hydrochloride

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