Prazosin hydrochloride

Pricing Availability   Qty
Description: α1 and α2B antagonist; also MT3 antagonist
Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride
Purity: ≥99% (HPLC)
Citations (12)
Literature (1)

Biological Activity for Prazosin hydrochloride

Prazosin hydrochloride is an α1 and α2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM). In prostate cancer cells, Prazosin induces DNA damage stress, Cdk1 inactivation, G2 checkpoint arrest and apoptosis. In mice bearing prostate cancer xenografts, oral administration of Prazosin reduces tumor mass.

Compound Libraries for Prazosin hydrochloride

Prazosin hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Prazosin hydrochloride

M. Wt 419.87
Formula C19H21N5O4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 19237-84-4
PubChem ID 68546
Smiles Cl.COC1=CC2=NC(=NC(N)=C2C=C1OC)N1CCN(CC1)C(=O)C1=CC=CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Prazosin hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 5

Preparing Stock Solutions for Prazosin hydrochloride

The following data is based on the product molecular weight 419.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.53 mL 47.63 mL 95.27 mL
1.25 mM 1.91 mL 9.53 mL 19.05 mL
2.5 mM 0.95 mL 4.76 mL 9.53 mL
12.5 mM 0.19 mL 0.95 mL 1.91 mL

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Product Datasheets for Prazosin hydrochloride

Certificate of Analysis / Product Datasheet
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References for Prazosin hydrochloride

References are publications that support the biological activity of the product.

Mathe et al (1996) Prazosin inhibits MK-801-induced hyperlocomotion and DA release in the nucleus accumbens. Eur.J.Pharmacol. 309 1 PMID: 8864686

Paul et al (1999) Characterisation of 2-[125I]iodomelatonin binding sites in syrian hamster peripheral organs. J.Pharmacol.Exp.Ther. 290 334 PMID: 10381796

Pickering and Niles (1990) Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus. Eur.J.Pharmacol. 175 71 PMID: 2157597

Merck Index 12 7897

Lin et al (2007) Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle. Neoplasia 9 830 PMID: 17971903

If you know of a relevant reference for Prazosin hydrochloride, please let us know.

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12 Citations for Prazosin hydrochloride

Citations are publications that use Tocris products. Selected citations for Prazosin hydrochloride include:

Ajmo et al (2009) Blockade of adrenoreceptors inhibits the splenic response to stroke. Cell Rep 218 47 PMID: 19371742

Corcoran et al (2014) Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice. Pain 34 51 PMID: 24381267

Sjöblom et al (2001) Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. Exp Neurol 108 625 PMID: 11518737

Huang et al (2009) Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex. Neuropsychopharmacology 34 1979 PMID: 19212317

Kahn et al (2016) The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med 8 511 PMID: 27138566

Moura et al (2006) Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol 149 1049 PMID: 17075569

Skelly and Weiner (2014) Chronic treatment with pra. or dulox. lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use. Brain Behav 4 468 PMID: 25161814

Delaney and Crane (2016) Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels. Sci Rep 6 19255 PMID: 26755335

Hughes et al (2013) Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury. J Clin Invest 154 1680 PMID: 23707289

Zhu et al (2007) Tyramine excites rat subthalamic neurons in vitro by a DA-dependent mechanism. Neuropharmacology 52 1169 PMID: 17291545

Zemkova et al (2011) NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842 PMID: 21828176

Tjen-A-Looi et al (2011) Central and peripheral mechanisms underlying gastric distention inhibitory reflex responses in hypercapnic-acidotic rats. Am J Physiol Heart Circ Physiol 300 H1003 PMID: 21217073

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Literature in this Area

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Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.