Prazosin hydrochloride

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Cat.No. 0623 - Prazosin hydrochloride | C19H21N5O4.HCl | CAS No. 19237-84-4
Description: α1 and α2B antagonist; also MT3 antagonist
Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (12)
Reviews
Literature (4)

Biological Activity

α1 and α2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM).

Compound Libraries

Prazosin hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 419.87
Formula C19H21N5O4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 19237-84-4
PubChem ID 68546
InChI Key WFXFYZULCQKPIP-UHFFFAOYSA-N
Smiles Cl.COC1=CC2=NC(=NC(N)=C2C=C1OC)N1CCN(CC1)C(=O)C1=CC=CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25
ethanol 5

Preparing Stock Solutions

The following data is based on the product molecular weight 419.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.53 mL 47.63 mL 95.27 mL
1.25 mM 1.91 mL 9.53 mL 19.05 mL
2.5 mM 0.95 mL 4.76 mL 9.53 mL
12.5 mM 0.19 mL 0.95 mL 1.91 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Mathe et al (1996) Prazosin inhibits MK-801-induced hyperlocomotion and DA release in the nucleus accumbens. Eur.J.Pharmacol. 309 1 PMID: 8864686

Paul et al (1999) Characterisation of 2-[125I]iodomelatonin binding sites in syrian hamster peripheral organs. J.Pharmacol.Exp.Ther. 290 334 PMID: 10381796

Pickering and Niles (1990) Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus. Eur.J.Pharmacol. 175 71 PMID: 2157597

Merck Index 12 7897


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Keywords: Prazosin hydrochloride, Prazosin hydrochloride supplier, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, antagonists, MT3, α1-adrenergic, alpha1-adrenergic, a1-adrenergic, Receptors, MT, Melatonin, Adrenergic, Alpha-1, (MT), Alpha-2, 0623, Tocris Bioscience

12 Citations for Prazosin hydrochloride

Citations are publications that use Tocris products. Selected citations for Prazosin hydrochloride include:

Kahn et al (2016) The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med 8 511 PMID: 27138566

Moura et al (2006) Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol 149 1049 PMID: 17075569

Corcoran et al (2014) Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice. Pain 34 51 PMID: 24381267

Huang et al (2009) Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex. Neuropsychopharmacology 34 1979 PMID: 19212317


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Literature in this Area

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