RS 79948 hydrochloride

Pricing Availability   Qty
Description: Potent and selective α2 antagonist
Chemical Name: (8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-dechydro-3-methoxy-12-(ethylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine hydrochloride
Purity: ≥99% (HPLC)
Citations (4)
Literature (2)

Biological Activity for RS 79948 hydrochloride

RS 79948 hydrochloride is a α2-adrenoreceptor antagonist (Kd values are; 0.18, 0.19 and 0.42 nM for α2B α2C and α2A, respectively in rat).

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data for RS 79948 hydrochloride

M. Wt 400.96
Formula C19H28N2O3S.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 186002-54-0
PubChem ID 9908991
Smiles [H][C@]12C4=C(C=C(OC)C=C4)CCN1C[C@]3([H])[C@](N(S(=O)(CC)=O)CCC3)([H])C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RS 79948 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 25

Preparing Stock Solutions for RS 79948 hydrochloride

The following data is based on the product molecular weight 400.96. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.98 mL 49.88 mL 99.76 mL
1.25 mM 2 mL 9.98 mL 19.95 mL
2.5 mM 1 mL 4.99 mL 9.98 mL
12.5 mM 0.2 mL 1 mL 2 mL

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Product Datasheets for RS 79948 hydrochloride

References for RS 79948 hydrochloride

References are publications that support the biological activity of the product.

Clark et al (1989) (8aα,12aα,13aα)-5,8,8a,9,10,11,12,12a,13,13a-Decahydro-3-methoxy-12-(ethylsulphonyl)-6H-isoquino[2,1-g][1,6]-naphthyridine, a potent and highly selective α2-adrenoceptor antagonist. J. Med. Chem. 32 2034 PMID: 2570150

Hume et al (1996) Evaluation in rat of RS-79948-197 as a potential PET ligand for central α2-adrenoceptors. Eur.J.Pharmacol. 317 67 PMID: 8982721

Uhlen et al (1998) [3H]RS79948-197 binding to rat, guinea pig and pig α2A-, α2B and α2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 343 93 PMID: 9551719

If you know of a relevant reference for RS 79948 hydrochloride, please let us know.

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4 Citations for RS 79948 hydrochloride

Citations are publications that use Tocris products. Selected citations for RS 79948 hydrochloride include:

Chen et al (2019) Molecular Mechanism for Ligand Recognition and Subtype Selectivity of α2C Adrenergic Receptor. Cell Reports 29 2936 PMID: 31801061

Qu et al (2019) Structural Basis of the Diversity of Adrenergic Receptors. Cell Reports 29 2929 PMID: 31801060

Hirono (2017) Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology 118 79 PMID: 28300552

Zacharia et al (2013) High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes. PLoS One 8 e65969 PMID: 23776582

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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