RS 79948 hydrochloride

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Cat.No. 0987 - RS 79948 hydrochloride | C19H28N2O3S.HCl | CAS No. 186002-54-0
Description: Potent and selective α2 antagonist
Chemical Name: (8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-dechydro-3-methoxy-12-(ethylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

α2-adrenoreceptor antagonist (Kd values are; 0.18, 0.19 and 0.42 nM for α2B α2C and α2A, respectively in rat).

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data

M. Wt 400.96
Formula C19H28N2O3S.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 186002-54-0
PubChem ID 9908991
InChI Key DZTZUOBWDBPPJQ-BQBHMPFISA-N
Smiles [H][C@]12C4=C(C=C(OC)C=C4)CCN1C[C@]3([H])[C@](N(S(=O)(CC)=O)CCC3)([H])C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 25 mM in water

References

References are publications that support the biological activity of the product.

Clark et al (1989) (8aα,12aα,13aα)-5,8,8a,9,10,11,12,12a,13,13a-Decahydro-3-methoxy-12-(ethylsulphonyl)-6H-isoquino[2,1-g][1,6]-naphthyridine, a potent and highly selective α2-adrenoceptor antagonist. J. Med. Chem. 32 2034 PMID: 2570150

Hume et al (1996) Evaluation in rat of RS-79948-197 as a potential PET ligand for central α2-adrenoceptors. Eur.J.Pharmacol. 317 67 PMID: 8982721

Uhlen et al (1998) [3H]RS79948-197 binding to rat, guinea pig and pig α2A-, α2B and α2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 343 93 PMID: 9551719


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2 Citations for RS 79948 hydrochloride

Citations are publications that use Tocris products. Selected citations for RS 79948 hydrochloride include:

Hirono (2017) Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology 118 79 PMID: 28300552

Zacharia et al (2013) High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes. PLoS One 8 e65969 PMID: 23776582


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