Adrenergic transporters (NET) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) widely distributed throughout the brain within noradrenergic neuronal plasma membranes. They are responsible for re-uptake of adrenalin and noradrenalin.
Adrenergic Transporter Inhibitors |
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Cat. No. | Product Name / Activity |
4456 | Amitriptyline hydrochloride |
5-HT and noradrenalin re-uptake inhibitor; also TrkA/B agonist | |
2831 | Bupropion hydrochloride |
Non-selective inhibitor of dopamine and noradrenalin transporters | |
3067 | Desipramine hydrochloride |
Selective inhibitor of noradrenalin transporters | |
4798 | (S)-Duloxetine hydrochloride |
Potent 5-HT and NA reuptake inhibitor; also blocks dopamine reuptake | |
7841 | Imipramine hydrochloride New |
Potent inhibitor of 5-HT and noradrenalin transporters; promotes immunostimulatory tumor microenvironment | |
1588 | Indatraline hydrochloride |
Potent noradrenalin uptake inhibitor; also inhibits 5-HT and dopamine uptake | |
1812 | Threo-methylphenidate hydrochloride |
Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant | |
3286 | Milnacipran hydrochloride |
5-HT and NA reuptake inhibitor (SNRI) | |
1025 | Nisoxetine hydrochloride |
Noradrenalin re-uptake inhibitor | |
1992 | Nomifensine |
Potent noradrenalin and dopamine uptake inhibitor. Antidepressant | |
1982 | Reboxetine mesylate |
Potent and selective noradrenalin uptake inhibitor; orally active | |
2175 | Tetrabenazine |
Potent inhibitor of vesicular monoamine transport; depletes noradrenalin stores | |
2011 | Tomoxetine hydrochloride |
Potent and selective noradrenalin re-uptake inhibitor | |
2917 | Venlafaxine hydrochloride |
5-HT and NA reuptake inhibitor (SNRI) | |
Substrates |
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Cat. No. | Product Name / Activity |
5169 | Noradrenaline bitartrate |
Endogenous adrenergic hormone and neurotransmitter | |
Other |
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Cat. No. | Product Name / Activity |
6717 | FFN 270 |
Fluorescent substrate for NET and VMAT2 |
Adrenergic transporters (NET) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) widely distributed throughout the brain within noradrenergic neuronal plasma membranes. They are responsible for the re-uptake of adrenalin, noradrenalin and (to a lesser extent) dopamine from the synaptic cleft back into vesicles for storage until later use, resulting in the termination of neurotransmitter action.
Adrenergic transporters contain the following structural motifs: 12-TM domains, extracellular loops, cytoplasmic C- and N-termini and putative phosphorylation sites. A role for NETs has been proposed in attention deficit disorder, substance abuse, neurodegenerative disorders and clinical depression.
Tocris offers the following scientific literature for Adrenergic Transporters to showcase our products. We invite you to request* your copy today!
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