Adrenergic Transporters

Adrenergic transporters (NET) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) widely distributed throughout the brain within noradrenergic neuronal plasma membranes. They are responsible for re-uptake of adrenalin and noradrenalin.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
4456 Amitriptyline hydrochloride
5-HT and noradrenalin re-uptake inhibitor; also TrkA/B agonist
4357 Bicifadine hydrochloride
Noradrenalin, 5-HT and dopamine re-uptake inhibitor
2322 BTS 54-505 hydrochloride
Potent SNRI; active metabolite of sibutramine (Cat. No. 2290)
2831 Bupropion hydrochloride
Non-selective inhibitor of dopamine and noradrenalin transporters
2833 Cocaine hydrochloride
Inhibitor of monoamine transporters
3067 Desipramine hydrochloride
Selective inhibitor of noradrenalin transporters
4798 (S)-Duloxetine hydrochloride
Potent 5-HT and NA reuptake inhibitor; also blocks dopamine reuptake
1588 Indatraline hydrochloride
Potent noradrenalin uptake inhibitor; also inhibits 5-HT and dopamine uptake
2545 Lofepramine
5-HT and noradrenalin re-uptake inhibitor (SNRI)
0935 Maprotiline hydrochloride
Noradrenalin re-uptake inhibitor
2148 (±)-McN 5652
Potent, orally active 5-HT uptake inhibitor. Also inhibits noradrenalin and dopamine uptake in vitro
1812 Threo-methylphenidate hydrochloride
Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant
3286 Milnacipran hydrochloride
5-HT and noradrenalin re-uptake inhibitor (SNRI)
1025 Nisoxetine hydrochloride
Noradrenalin re-uptake inhibitor
1992 Nomifensine
Potent noradrenalin and dopamine uptake inhibitor. Antidepressant
1982 Reboxetine mesylate
Potent, selective noradrenalin uptake inhibitor; orally active
2290 Sibutramine hydrochloride
5-HT and noradrenalin re-uptake inhibitor (SNRI)
3145 Talopram hydrochloride
Potent, selective inhibitor of noradrenalin transporters
4352 Talsupram hydrochloride
Selective inhibitor of noradrenalin transporters
2175 Tetrabenazine
Potent inhibitor of vesicular monoamine transport; depletes noradrenalin stores
2011 Tomoxetine hydrochloride
Potent, selective noradrenalin re-uptake inhibitor
2917 Venlafaxine hydrochloride
Dual serotonin/noradrenalin re-uptake inhibitor
4194 WY 45233 succinate
Dual serotonin/noradrenalin re-uptake inhibitor

Substrates

Cat No Product Name / Activity
5169 Noradrenaline bitartrate
Endogenous adrenergic hormone and neurotransmitter

Adrenergic transporters (NET) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) widely distributed throughout the brain within noradrenergic neuronal plasma membranes. They are responsible for the re-uptake of adrenalin, noradrenalin and (to a lesser extent) dopamine from the synaptic cleft back into vesicles for storage until later use, resulting in the termination of neurotransmitter action.

Adrenergic transporters contain the following structural motifs: 12-TM domains, extracellular loops, cytoplasmic C- and N-termini and putative phosphorylation sites. A role for NETs has been proposed in attention deficit disorder, substance abuse, neurodegenerative disorders and clinical depression.

External sources of pharmacological information for Adrenergic Transporters :

    Literature for Adrenergic Transporters

    Cardiovascular

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    A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

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    • Heart Failure

    Adrenergic Transporter Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human SLC6A2 NM_001043 P23975
    Mouse Slc6a2 NM_009209 O55192
    Rat Slc6a2 NM_031343 Q63380