Adrenergic Transporters

Adrenergic transporters (NET) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) widely distributed throughout the brain within noradrenergic neuronal plasma membranes. They are responsible for re-uptake of adrenalin and noradrenalin.

Products
Background
Gene Data

Adrenergic Transporter Inhibitors

Cat. No. Product Name / Activity
2831 Bupropion hydrochloride
Non-selective inhibitor of dopamine and noradrenalin transporters
3067 Desipramine hydrochloride
Selective inhibitor of noradrenalin transporters
4798 (S)-Duloxetine hydrochloride
Potent 5-HT and NA reuptake inhibitor; also blocks dopamine reuptake
7841 Imipramine hydrochloride
Potent inhibitor of 5-HT and noradrenalin transporters; promotes immunostimulatory tumor microenvironment
1588 Indatraline hydrochloride
Potent noradrenalin uptake inhibitor; also inhibits 5-HT and dopamine uptake
3286 Milnacipran hydrochloride
5-HT and NA reuptake inhibitor (SNRI)
1025 Nisoxetine hydrochloride
Noradrenalin re-uptake inhibitor
1992 Nomifensine
Potent noradrenalin and dopamine uptake inhibitor. Antidepressant
1982 Reboxetine mesylate
Potent and selective noradrenalin uptake inhibitor; orally active
2175 Tetrabenazine
Potent inhibitor of vesicular monoamine transport; depletes noradrenalin stores
2011 Tomoxetine hydrochloride
Potent and selective noradrenalin re-uptake inhibitor
2917 Venlafaxine hydrochloride
5-HT and NA reuptake inhibitor (SNRI)

Substrates

Cat. No. Product Name / Activity
5169 Noradrenaline bitartrate
Endogenous adrenergic hormone and neurotransmitter

Other

Cat. No. Product Name / Activity
6717 FFN 270
Fluorescent substrate for NET and VMAT2

Adrenergic transporters (NET) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) widely distributed throughout the brain within noradrenergic neuronal plasma membranes. They are responsible for the re-uptake of adrenalin, noradrenalin and (to a lesser extent) dopamine from the synaptic cleft back into vesicles for storage until later use, resulting in the termination of neurotransmitter action.

Adrenergic transporters contain the following structural motifs: 12-TM domains, extracellular loops, cytoplasmic C- and N-termini and putative phosphorylation sites. A role for NETs has been proposed in attention deficit disorder, substance abuse, neurodegenerative disorders and clinical depression.

External sources of pharmacological information for Adrenergic Transporters :

Adrenergic Transporter Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human SLC6A2 NM_001043 P23975
Mouse Slc6a2 NM_009209 O55192
Rat Slc6a2 NM_031343 Q63380