UK 14,304

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Cat.No. 0425 - UK 14,304 | C11H10BrN5 | CAS No. 59803-98-4
Description: α2 agonist
Chemical Name: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline
Datasheet
Citations (4)
Reviews
Literature (6)

Biological Activity

Full α2 adrenergic agonist. Centrally active following systemic administration in vivo.

Available as part of the α2-Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™. Water-soluble Salt also available.

Compound Libraries

UK 14,304 is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 292.14
Formula C11H10BrN5
Storage Store at RT
CAS Number 59803-98-4
PubChem ID 2435
InChI Key XYLJNLCSTIOKRM-UHFFFAOYSA-N
Smiles BrC1=C(NC2=NCCN2)C=CC2=NC=CN=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in DMSO

References

References are publications that support the biological activity of the product.

Andorn et al (1988) Specific [3H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α2-adrenergic selectivity and different affinities for GTP. Life Sci. 43 1805 PMID: 2904634

Chopin et al (1999) Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxyDA lesions of the nigrostriatal pathway. J.Pharmacol.Exp.Ther. 288 798 PMID: 9918591

Macdonald et al (1997) Gene trageting - homing in on α2-adrenoceptor-subtype function. TiPS 18 211 PMID: 9227000


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Keywords: UK 14,304, UK 14,304 supplier, α2-adrenoceptor, alpha2-adrenoceptors, a2-adrenoceptors, agonists, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, Receptors, UK14304, Adrenergic, Alpha-2, 0425, Tocris Bioscience

4 Citations for UK 14,304

Citations are publications that use Tocris products. Selected citations for UK 14,304 include:

Sadeghi et al (2015) μ-Opioid receptor activation and noradrenaline transport inhibition by tapen. in rat single locus coeruleus neurons. J Pharmacol Exp Ther 172 460 PMID: 24372103

Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888

Jasmin et al (2002) The NK1 receptor mediates both the hyperalgesia and the resistance to mor. in mice lacking noradrenaline. Proc Natl Acad Sci U S A 99 1029 PMID: 11805341

Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Neurosci 336 127 PMID: 20959363


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Literature in this Area

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