UK 14,304

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Cat.No. 0425 - UK 14,304 | C11H10BrN5 | CAS No. 59803-98-4
Description: α2 agonist
Chemical Name: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline
Datasheet
Citations (3)

Biological Activity

Full α2 adrenergic agonist. Centrally active following systemic administration in vivo. Also available as part of the α2-Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™. Water soluble salt version UK 14,304 tartrate (Cat. No. 2466) also available.

Compound Libraries

UK 14,304 is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 292.14
Formula C11H10BrN5
Storage Store at RT
CAS Number 59803-98-4
PubChem ID 2435
InChI Key XYLJNLCSTIOKRM-UHFFFAOYSA-N
Smiles BrC1=C(NC2=NCCN2)C=CC2=NC=CN=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 292.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.12 mL 34.23 mL
5 mM 0.68 mL 3.42 mL 6.85 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Andorn et al (1988) Specific [3H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α2-adrenergic selectivity and different affinities for GTP. Life Sci. 43 1805 PMID: 2904634

Chopin et al (1999) Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J.Pharmacol.Exp.Ther. 288 798 PMID: 9918591

Macdonald et al (1997) Gene trageting - homing in on α2-adrenoceptor-subtype function. TiPS 18 211 PMID: 9227000


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Keywords: α2-adrenoceptor alpha2-adrenoceptors a2-adrenoceptors agonists α2-Adrenergic alpha2-Adrenergic a2-adrenergic Receptors UK14304 Adrenergic Alpha-2 Receptors

3 Citations for UK 14,304

Citations are publications that use Tocris products. Selected citations for UK 14,304 include:

Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Neurosci 336 127 PMID: 20959363

Jasmin et al (2002) The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline. Proc Natl Acad Sci U S A 99 1029 PMID: 11805341

Sadeghi et al (2015) μ-Opioid receptor activation and noradrenaline transport inhibition by tapentadol in rat single locus coeruleus neurons. J Pharmacol Exp Ther 172 460 PMID: 24372103


Do you know of a great paper that uses UK 14,304 from Tocris? If so please let us know.

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