Full α2 adrenergic agonist. Centrally active following systemic administration in vivo. Also available as part of the α2-Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™. Water soluble salt version UK 14,304 tartrate (Cat. No. 2466) also available.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in DMSO|
Preparing Stock Solutions
The following data is based on the product molecular weight 292.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.42 mL||17.12 mL||34.23 mL|
|5 mM||0.68 mL||3.42 mL||6.85 mL|
|10 mM||0.34 mL||1.71 mL||3.42 mL|
|50 mM||0.07 mL||0.34 mL||0.68 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Andorn et al (1988) Specific [3H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α2-adrenergic selectivity and different affinities for GTP. Life Sci. 43 1805 PMID: 2904634
Chopin et al (1999) Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J.Pharmacol.Exp.Ther. 288 798 PMID: 9918591
Macdonald et al (1997) Gene trageting - homing in on α2-adrenoceptor-subtype function. TiPS 18 211 PMID: 9227000
If you know of a relevant reference for UK 14,304, please let us know.
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Keywords: α2-adrenoceptor alpha2-adrenoceptors a2-adrenoceptors agonists α2-Adrenergic alpha2-Adrenergic a2-adrenergic Receptors UK14304 Adrenergic Alpha-2 Receptors
3 Citations for UK 14,304
Citations are publications that use Tocris products. Selected citations for UK 14,304 include:
Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Neurosci 336 127 PMID: 20959363
Jasmin et al (2002) The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline. Proc Natl Acad Sci U S A 99 1029 PMID: 11805341
Sadeghi et al (2015) μ-Opioid receptor activation and noradrenaline transport inhibition by tapentadol in rat single locus coeruleus neurons. J Pharmacol Exp Ther 172 460 PMID: 24372103
Do you know of a great paper that uses UK 14,304 from Tocris? If so please let us know.