UK 14,304 tartrate

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Cat.No. 2466 - UK 14,304 tartrate | C11H10BrN5.C4H6O6 | CAS No. 70359-46-5
Description: α2 agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)
Chemical Name: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline tartrate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Water-soluble form of UK 14,304 (Cat. No. 0425). Full α2 adrenergic agonist. Centrally active following systemic administration in vivo.

Technical Data

M. Wt 442.23
Formula C11H10BrN5.C4H6O6
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 70359-46-5
PubChem ID 11236066
InChI Key QZHBYNSSDLTCRG-UHFFFAOYSA-N
Smiles O=C(O)C(O)C(O)C(O)=O.BrC2=C(NC3=NCCN3)C=CC1=NC=CN=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 22.11 50

Preparing Stock Solutions

The following data is based on the product molecular weight 442.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.31 mL 22.61 mL
5 mM 0.45 mL 2.26 mL 4.52 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Cambridge (1981) UK-14,304, a potent and selective alpha2-gonist for the characterisation of alpha-adrenoceptor subtypes. Eur.J.Pharmacol. 72 413 PMID: 6115759

Andorn et al (1988) Specific [3H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α2-adrenergic selectivity and different affinities for GTP. Life Sci. 43 1805 PMID: 2904634

Macdonald et al (1997) Gene targeting - homing in on α2-adrenoceptor-subtype function. TiPS 18 211 PMID: 9227000

Chopin et al (1999) Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J.Pharmacol.Exp.Ther. 288 798 PMID: 9918591


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Citations for UK 14,304 tartrate

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