UK 14,304 tartrate

Pricing Availability   Qty
Description: α2 agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)
Chemical Name: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline tartrate
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for UK 14,304 tartrate

UK 14,304 tartrate is a water-soluble form of UK 14,304 (Cat. No. 0425). Full α2 adrenergic agonist. Centrally active following systemic administration in vivo.

Technical Data for UK 14,304 tartrate

M. Wt 442.23
Formula C11H10BrN5.C4H6O6
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 70359-46-5
PubChem ID 11236066
Smiles O=C(O)C(O)C(O)C(O)=O.BrC2=C(NC3=NCCN3)C=CC1=NC=CN=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for UK 14,304 tartrate

Solvent Max Conc. mg/mL Max Conc. mM
water 22.11 50

Preparing Stock Solutions for UK 14,304 tartrate

The following data is based on the product molecular weight 442.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.52 mL 22.61 mL 45.23 mL
2.5 mM 0.9 mL 4.52 mL 9.05 mL
5 mM 0.45 mL 2.26 mL 4.52 mL
25 mM 0.09 mL 0.45 mL 0.9 mL

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Product Datasheets for UK 14,304 tartrate

Certificate of Analysis / Product Datasheet
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References for UK 14,304 tartrate

References are publications that support the biological activity of the product.

Cambridge (1981) UK-14,304, a potent and selective alpha2-gonist for the characterisation of alpha-adrenoceptor subtypes. Eur.J.Pharmacol. 72 413 PMID: 6115759

Andorn et al (1988) Specific [3H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α2-adrenergic selectivity and different affinities for GTP. Life Sci. 43 1805 PMID: 2904634

Macdonald et al (1997) Gene targeting - homing in on α2-adrenoceptor-subtype function. TiPS 18 211 PMID: 9227000

Chopin et al (1999) Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxyDA lesions of the nigrostriatal pathway. J.Pharmacol.Exp.Ther. 288 798 PMID: 9918591

If you know of a relevant reference for UK 14,304 tartrate, please let us know.

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1 Citation for UK 14,304 tartrate

Citations are publications that use Tocris products. Selected citations for UK 14,304 tartrate include:

Harris et al (2018) Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci 38 8922 PMID: 30150361

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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