Atipamezole hydrochloride

Pricing Availability   Qty
Description: Selective α2 antagonist
Chemical Name: 5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazole hydrochloride
Purity: ≥99% (HPLC)
Citations (2)
Reviews (1)
Literature (2)

Biological Activity for Atipamezole hydrochloride

Atipamezole hydrochloride is a selective α2-adrenergic receptor antagonist (Ki values are 1.1, 1.0, 0.89, 1300 and 6500 nM for α2A, α2B, α2C, α1A and α1B receptors respectively). Brain penetrant.

Compound Libraries for Atipamezole hydrochloride

Atipamezole hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Atipamezole hydrochloride

M. Wt 248.75
Formula C14H16N2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 104075-48-1
PubChem ID 13649426
Smiles CCC2(C3=CN=CN3)CC1=CC=CC=C1C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Atipamezole hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 24.87 100
DMSO 24.87 100

Preparing Stock Solutions for Atipamezole hydrochloride

The following data is based on the product molecular weight 248.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.02 mL 20.1 mL 40.2 mL
5 mM 0.8 mL 4.02 mL 8.04 mL
10 mM 0.4 mL 2.01 mL 4.02 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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Product Datasheets for Atipamezole hydrochloride

References for Atipamezole hydrochloride

References are publications that support the biological activity of the product.

Virtanen et al (1989) Highly selective and specific antagonism of central and peripheral alpha 2-adrenoceptors by atipamezole. Arch.Int.Pharmacodyn.Ther. 297 190 PMID: 2567152

Puurunen et al (2001) An α2-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats. Neuropharmacology 40 597 PMID: 11249969

Jurgens et al (2007) α2A adrenergic receptor activation inhibits epileptiform activity in the rat hippocampal CA3 region. Mol.Pharmacol. 71 1572 PMID: 17341653

If you know of a relevant reference for Atipamezole hydrochloride, please let us know.

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Keywords: Atipamezole hydrochloride, Atipamezole hydrochloride supplier, selective, a-adrenergic, alpha-adrenergic, α-adrenergic, antagonists, receptors, alpha-adrenoceptors, a-adrenoceptors, αadrenoceptors, Adrenergic, Alpha-2, Receptors, 2937, Tocris Bioscience

2 Citations for Atipamezole hydrochloride

Citations are publications that use Tocris products. Selected citations for Atipamezole hydrochloride include:

Harris et al (2018) Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci 38 8922 PMID: 30150361

Hughes et al (2013) Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury. Gastroenterology 154 1680 PMID: 23707289

Do you know of a great paper that uses Atipamezole hydrochloride from Tocris? Please let us know.

Reviews for Atipamezole hydrochloride

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behavioral pharmacology in rats.
By Corinne Kiessling on 01/04/2018
Assay Type: In Vivo
Species: Rat

Behavioral neuropharmacology. Atimpamezole (0.1-1.0 mg/mL) was dissolved in 50-100% DMSO and was injected systemically in rats. Atipamezole is highly selective for the alpha2- noradrenergic receptor, and was used as a reference compound during behaviral testing.

This comes out of solution easily, even with sonicating. After fully dissolving in DMSO, add water slowly and continue to vortex or sonicate.

Literature in this Area

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