Selective α2-adrenergic receptor antagonist (Ki values are 1.1, 1.0, 0.89, 1300 and 6500 nM for α2A, α2B, α2C, α1A and α1B receptors respectively). Brain penetrant.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 248.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.02 mL||20.1 mL||40.2 mL|
|5 mM||0.8 mL||4.02 mL||8.04 mL|
|10 mM||0.4 mL||2.01 mL||4.02 mL|
|50 mM||0.08 mL||0.4 mL||0.8 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Virtanen et al (1989) Highly selective and specific antagonism of central and peripheral alpha 2-adrenoceptors by atipamezole. Arch.Int.Pharmacodyn.Ther. 297 190 PMID: 2567152
Puurunen et al (2001) An α2-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats. Neuropharmacology 40 597 PMID: 11249969
Jurgens et al (2007) α2A adrenergic receptor activation inhibits epileptiform activity in the rat hippocampal CA3 region. Mol.Pharmacol. 71 1572 PMID: 17341653
If you know of a relevant reference for Atipamezole hydrochloride, please let us know.
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Keywords: Atipamezole hydrochloride, supplier, selective, a-adrenergic, alpha-adrenergic, α-adrenergic, antagonists, receptors, alpha-adrenoceptors, a-adrenoceptors, αadrenoceptors, Adrenergic, Alpha-2, Receptors, Tocris Bioscience
1 Citation for Atipamezole hydrochloride
Citations are publications that use Tocris products. Selected citations for Atipamezole hydrochloride include:
Hughes et al (2013) Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury. Gastroenterology 154 1680 PMID: 23707289
Do you know of a great paper that uses Atipamezole hydrochloride from Tocris? If so please let us know.
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