RX 821002 hydrochloride

Pricing Availability   Qty
Description: Potent, selective α2D antagonist
Chemical Name: 2-(2,3-Dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride
Purity: ≥99% (HPLC)
Citations (7)
Literature (2)

Biological Activity for RX 821002 hydrochloride

RX 821002 hydrochloride is a potent, selective α2-adrenoceptor antagonist with very low affinity for imidazoline sites. Displays selectivity for the α2D over the α2A subtypes (pKd values are 9.7 and 8.2 respectively).

Compound Libraries for RX 821002 hydrochloride

RX 821002 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for RX 821002 hydrochloride

M. Wt 270.72
Formula C12H14N2O3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 109544-45-8
PubChem ID 11957683
Smiles Cl.COC1(COC2=CC=CC=C2O1)C1=NCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RX 821002 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 100
DMSO 27.07 100

Preparing Stock Solutions for RX 821002 hydrochloride

The following data is based on the product molecular weight 270.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.69 mL 18.47 mL 36.94 mL
5 mM 0.74 mL 3.69 mL 7.39 mL
10 mM 0.37 mL 1.85 mL 3.69 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets for RX 821002 hydrochloride

Certificate of Analysis / Product Datasheet
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References for RX 821002 hydrochloride

References are publications that support the biological activity of the product.

Erdbrugger et al (1995) Does [3H]2-methoxy-idazoxan (RX 821002) detect more alpha-2-adrenoceptor agonist high-affinity sites than [3H]rauwolscine? A comparison of nine tissues and cell lines. J.Pharmacol.Exp.Ther. 273 1287 PMID: 7791100

O'Rourke et al (1994) Characterisation of [3H]RX 821002 binding to alpha-2 adrenergic receptor subtypes. J.Pharmacol.Exp.Ther. 268 1362 PMID: 7908054

Trendelenburg et al (1996) Antagonists that differentiate between α2A- and α2D-adrenoceptors. Naunyn Schmiedebergs Arch.Pharmacol. 353 245 PMID: 8692278

If you know of a relevant reference for RX 821002 hydrochloride, please let us know.

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7 Citations for RX 821002 hydrochloride

Citations are publications that use Tocris products. Selected citations for RX 821002 hydrochloride include:

Uchański et al (2019) An improved yeast surface display platform for the screening of nanobody immune libraries. Sci Rep 9 382 PMID: 30674983

Li et al (2017) Pericytes impair capillary blood flow and motor function after chronic spinal cord injury. Nat Med 23 733 PMID: 28459438

Alves et al (2014) Both α1- and α2-adrenoceptors in the insular cortex are involved in the cardiovascular responses to acute restraint stress in rats. J Chem Biol 9 e83900 PMID: 24404141

Hott et al (2012) Both α1- and β1-adrenoceptors in the bed nucleus of the stria terminalis are involved in the expression of conditioned contextual fear. Br J Pharmacol 167 207 PMID: 22506532

Do you know of a great paper that uses RX 821002 hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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