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Adrenergic β2 Receptors

The adrenergic β2 receptor (β2-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes α1A, α1B, α1D, α2A, α2B, α2C, β1 and β3. They are located primarily in the CNS, heart, kidney and muscle.

Products
Background
Literature
Gene Data

Agonists
Cat No Product Name / Activity
6219 Arformoterol tartrate
Long-acting β2 agonist (LABA)
1448 Formoterol hemifumarate
Potent and selective β2 agonist
1102 Procaterol hydrochloride
Potent β2 agonist
0634 Salbutamol hemisulfate
β agonist (β2 > β1)
4712 Salmeterol xinafoate
Long-acting β2 agonist; bronchodilator
1051 Zinterol hydrochloride
Selective β2 agonist

Antagonists
Cat No Product Name / Activity
0821 ICI 118,551 hydrochloride
Very selective β2 antagonist/inverse agonist

Ligand-sets
Cat No Product Name / Activity
1873 β-Adrenoceptor Agonist Tocriset™
Selection of 3 β-adrenoceptor agonists (Cat. Nos. 0948, 1747 and 1660)
1874 β-Adrenoceptor Antagonist Tocriset™
Selection of 3 β-adrenoceptor antagonists (Cat. Nos. 1024, 0821 and 1511)

Related Targets

The adrenergic β2 receptor (β2-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes α1A, α1B, α1D, α2A, α2B, α2C, β1 and β3. They are located primarily in the CNS, heart, kidney and muscle where they are involved in smooth muscle relaxation (e.g. bronchodilation). The human adrenergic β2 receptor gene has been localized to chromosome 5 (5q31-q32)

External sources of pharmacological information for Adrenergic β2 Receptors :

Literature for Adrenergic β2 Receptors

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Adrenergic β2 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human ADRB2 NM_000024 P07550
Mouse Adrb2 NM_007420 P18762
Rat Adrb2 NM_012492 P10608