SKF 86466 hydrochloride
Potent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 232.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.31 mL||21.54 mL||43.08 mL|
|5 mM||0.86 mL||4.31 mL||8.62 mL|
|10 mM||0.43 mL||2.15 mL||4.31 mL|
|50 mM||0.09 mL||0.43 mL||0.86 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Roesler et al (1986) Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat. J.Pharmacol.Exp.Ther. 236 1 PMID: 2867209
Schafers et al (1990) An evaluation of the alpha-adrenoceptor antagonism produced by SK&F 86466 in healthy normotensive males. Br.J.Clin.Pharmacol. 30 884 PMID: 1981137
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Keywords: Selective α2-adrenoceptor alpha2-adrenoceptor a2-adrenoceptor antagonist α2-Adrenergic alpha2-Adrenergic a2-adrenergic Receptors SKF86466 SK&F 86466 SKF Adrenergic Alpha-2 Receptors
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