SKF 86466 hydrochloride

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Cat.No. 3866 - SKF 86466 hydrochloride | C11H14ClN.HCl | CAS No. 86129-54-6
Description: Potent and selective α2 antagonist
Chemical Name: 6-Chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

Potent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.

Technical Data

M. Wt 232.15
Formula C11H14ClN.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 86129-54-6
PubChem ID 10220250
Smiles CN2CCC1=CC=CC(Cl)=C1CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 23.21 100
water 23.21 100

Preparing Stock Solutions

The following data is based on the product molecular weight 232.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.31 mL 21.54 mL 43.08 mL
5 mM 0.86 mL 4.31 mL 8.62 mL
10 mM 0.43 mL 2.15 mL 4.31 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Roesler et al (1986) Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat. J.Pharmacol.Exp.Ther. 236 1 PMID: 2867209

Schafers et al (1990) An evaluation of the alpha-adrenoceptor antagonism produced by SK&F 86466 in healthy normotensive males. Br.J.Clin.Pharmacol. 30 884 PMID: 1981137

Hieble et al (1985) Selective Alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor sensitivity. J.Pharmacol.Exp.Ther. 236 90 PMID:

If you know of a relevant reference for SKF 86466 hydrochloride, please let us know.

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Keywords: Selective α2-adrenoceptor alpha2-adrenoceptor a2-adrenoceptor antagonist α2-Adrenergic alpha2-Adrenergic a2-adrenergic Receptors SKF86466 SK&F 86466 SKF Adrenergic Alpha-2 Receptors

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