ARC 239 dihydrochloride

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Description: α2B antagonist
Chemical Name: 2-[2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for ARC 239 dihydrochloride

ARC 239 dihydrochloride is a selective α2B adrenoceptor antagonist (pKD values are 8.8, 6.7 and 6.4 at α2B, α2A, and α2D receptors respectively).

Licensing Information

Sold with the permission of Boehringer Ingelheim GmbH

Technical Data for ARC 239 dihydrochloride

M. Wt 480.43
Formula C24H29N3O3.2HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 55974-42-0
PubChem ID 10345075
Smiles Cl.Cl.COC1=CC=CC=C1N1CCN(CCN2C(=O)C3=C(C=CC=C3)C(C)(C)C2=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ARC 239 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 48.04 100

Preparing Stock Solutions for ARC 239 dihydrochloride

The following data is based on the product molecular weight 480.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.41 mL 20.81 mL
5 mM 0.42 mL 2.08 mL 4.16 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets for ARC 239 dihydrochloride

Certificate of Analysis / Product Datasheet
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References for ARC 239 dihydrochloride

References are publications that support the biological activity of the product.

Bylund et al (1988) Alpha-2A and alpha-2B adrenergic subtypes: antagonist binding in tissues and cell lines containing only one subtype. J.Pharmacol.Exp.Ther. 245 600 PMID: 2835476

Fuder and Selback (1993) Characterisation of sensory neurotransmission and its inhibition via α2B-adrenoceptors and via non-α2 adrenoceptors in rabbit iris. Naunyn Schmiedebergs Arch.Pharmacol. 347 394 PMID: 7685502

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1 Citation for ARC 239 dihydrochloride

Citations are publications that use Tocris products. Selected citations for ARC 239 dihydrochloride include:

Kahn et al (2016) The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med 8 511 PMID: 27138566

Do you know of a great paper that uses ARC 239 dihydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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