ARC 239 dihydrochloride
Selective α2B adrenoceptor antagonist (pKD values are 8.8, 6.7 and 6.4 at α2B, α2A, and α2D receptors respectively). Also available as part of the α2-Adrenoceptor Tocriset™.
Sold with the permission of Boehringer Ingelheim GmbH
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 480.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.08 mL||10.41 mL||20.81 mL|
|5 mM||0.42 mL||2.08 mL||4.16 mL|
|10 mM||0.21 mL||1.04 mL||2.08 mL|
|50 mM||0.04 mL||0.21 mL||0.42 mL|
References are publications that support the products' biological activity.
Bylund et al (1988) Alpha-2A and alpha-2B adrenergic subtypes: antagonist binding in tissues and cell lines containing only one subtype. J.Pharmacol.Exp.Ther. 245 600 PMID: 2835476
Fuder and Selback (1993) Characterisation of sensory neurotransmission and its inhibition via α2B-adrenoceptors and via non-α2 adrenoceptors in rabbit iris. Naunyn Schmiedebergs Arch.Pharmacol. 347 394 PMID: 7685502
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