BRL 44408 maleate

Pricing Availability Delivery Time Qty
Cat.No. 1133 - BRL 44408 maleate | C13H17N3.C4H4O4 | CAS No. 681806-46-2
Description: Selective α2A antagonist
Chemical Name: 2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole maleate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective α2A-adrenoceptor antagonist (Ki = 1.7 nM and 144.5 nM at α2A and α2B-adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration. Also available as part of the α2-Adrenoceptor Tocriset™.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M. Wt 331.37
Formula C13H17N3.C4H4O4
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 681806-46-2
PubChem ID 10382026
InChI Key DDIQGSUEJOOQQQ-BTJKTKAUSA-N
Smiles OC(=O)\C=C/C(O)=O.CC1N(CC2=NCCN2)CC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
phosphate buffered saline 33.14 100
water 33.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 331.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.02 mL 15.09 mL 30.18 mL
5 mM 0.6 mL 3.02 mL 6.04 mL
10 mM 0.3 mL 1.51 mL 3.02 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Callado et al (1999) α2A-But not α2B/C-adrenoceptors modulate noradrenaline release in rat locus coeruleus: voltammetric data. Eur.J.Pharmacol. 366 35 PMID: 10064149

Gavin et al (1997) α2C-adrenoceptors mediate contractile responses to noradrenaline in the human saphenous vein. Naunyn Schmiedebergs Arch.Pharmacol. 355 406 PMID: 9089673

Kiss et al (1995) Subtype-specificity of the presynaptic α2-adrenoceptors modulating hippocampal norepinephrine release in rat. Brain Res. 674 238 PMID: 7796102

Young et al (1989) Novel α2-adrenoceptor antagonists show selectivity for α2A- and α2B-adrenoceptor subtypes. Eur.J.Pharmacol. 168 381 PMID: 2573535


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Keywords: Selective alpha2A-adrenoceptor a2a-adrenoceptor a2a-Adrenergic a2a-adrenergic antagonists Receptors BRL44408 maleate GlaxoSmithKline GSK Adrenergic Alpha-2 Receptors

1 Citation for BRL 44408 maleate

Citations are publications that use Tocris products. Selected citations for BRL 44408 maleate include:

Backman et al (2013) Alpha-2 adrenergic stimulation triggers Achilles tenocyte hypercellularity: Comparison between two model systems. Scand J Med Sci Sports 23 687 PMID: 22292987


Do you know of a great paper that uses BRL 44408 maleate from Tocris? If so please let us know.

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