Amyloid β Peptides

Amyloid β (Aβ) peptides are the major component of amyloid plaques found in the brains of Alzheimer's patients. Aβ is formed from the progressive cleavage of amyloid precursor protein (APP) by β- and γ-secretase. Two Aβ peptides are formed from APP degradation.

Gene Data


Cat No Product Name / Activity
5343 TPPB
APP modulator; also high affinity PKC activator


Cat No Product Name / Activity
4283 Begacestat
γ-secretase inhibitor; lowers Aβ40 and Aβ42 levels
2870 BMS 299897
γ-secretase inhibitor; reduces Aβ levels
4924 CEP 1347
Neuroprotective; blocks Aβ-induced cortical neuron apoptosis. Also inhibitor of JNK signaling
3360 CGP 52411
Inhibits Aβ42 fibril formation. Also EGFR inhibitor
2442 CGP 53353
Inhibitor of de novo Aβ42 assembly
2654 Compound W
γ-secretase inhibitor; reduces Aβ42 levels
2634 DAPT
γ-secretase inhibitor; reduces Aβ42 levels
4524 EGCG
Inhibits formation of amyloid fibrils
4495 Flurizan
γ-secretase inhibitor; lowers Aβ42 levels in vitro
2677 JLK 6
Inhibitor of γ-secretase-mediated βAPP processing
2627 L-685,458
Potent and selective γ-secretase inhibitor; inhibits Aβ40 and Aβ42
4000 MRK 560
γ-secretase inhibitor; attenuates amyloid plaque deposition
5398 NQTrp
Potent inhibitor of Aβ oligomer and fibril formation
5751 PF 3084014 hydrobromide
Potent γ-secretase inhibitor
2408 Ro 90-7501
Inhibitor of Aβ42 fibril formation
4699 SEN 1269
Amyloid-β aggregation inhibitor
4426 Tanshinone IIA
Inhibits Aβ aggregation; inhibits NF-κB and AP-1 DNA binding


Cat No Product Name / Activity
5053 AC 186
Decreases Aβ levels in combination with ACP-105; ERβ agonist
3391 Amyloid β-peptide (42-1) (human)
Inactive control peptide for amyloid β-peptide (1-42) (Cat. No. 1428)
1191 Amyloid β-Peptide (1-40) (human)
Amyloid β-protein fragment
2424 Amyloid β-peptide (1-40) (rat)
Amyloid β-protein fragment
1428 Amyloid β-Peptide (1-42) (human)
Predominant amyloid β-protein fragment
2425 Amyloid β-peptide (1-42) (rat)
Predominant amyloid β-protein fragment
1938 Amyloid β-Peptide (1-43) (human)
Amyloid β-protein fragment
1894 Amyloid β-Peptide (12-28) (human)
Amyloid β-peptide; minimum required for binding to brain proteins
1429 Amyloid β-peptide (25-35) (human)
Human amyloid β-protein fragment functionally required for neurotoxicity
5908 Bis-ANS
Fluorescent probe for nonpolar cavities in proteins; used to detect Aβ fibres
3945 Colivelin
Neuroprotective peptide; protects against β-amyloid neurotoxicity
4803 CRANAD 2
Near-infrared probe that detects Aβ40 aggregates
3713 Cryptotanshinone
Reduces Aβ generation. Also displays multiple other activities
3201 Dimebon dihydrochloride
Neuroprotectant; protects against β-amyloid neurotoxicity
5081 J 147
Neuroprotective and neurotrophic compound; reduces Aβ40 and Aβ42 levels
3144 K 114
Amyloid fibril-specific fluorescent dye
4084 LPYFD-NH2
Binds Aβ; protects from aggregation induced toxicity
4920 Methoxy-X04
Fluorescent amyloid β detector; brain penetrant
3619 Tramiprosate
Targets soluble Aβ to decrease amyloid plaque deposition. Also GABA analog
1098 Tranilast
Antiallergic; binds to Aβ40 monomers
1634 Y-29794 oxalate
Inhibitor of prolyl endopeptidase; prevents amyloid β-peptide-like deposition in vivo

Related Targets

    Amyloid β (Aβ) peptides are the major component of amyloid plaques found in the brains of Alzheimer's patients. Aβ is formed from the progressive cleavage of amyloid precursor protein (APP) by β- and γ-secretase. Two Aβ peptides are formed from APP degradation; Aβ40 and Aβ42. Aβ40 is the most abundant form, but Aβ42 is more fibrillogenic, thus is associated with disease states.

    Mutations in APP have been linked to early onset Alzheimer's disease, as proteolytic cleavage of the altered protein increases the levels of Aβ42 relative to Aβ40. Furthermore, Aβ proteins have been associated with other diseases including Lewy body dementia, inclusion body myositis and cerebral amyloid angiopathy.

    Literature for Amyloid β Peptides

    Tocris offers the following scientific literature for Amyloid β Peptides to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


    Neurodegeneration Product Guide

    A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

    • Alzheimer's disease
    • Parkinson's disease
    • Huntington's disease

    Alzheimer's Poster

    Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

    Amyloid β Peptide Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    APP1 Human APLP1 NM_001024807 P51693
    Mouse Aplp1 NM_007467 Q03157
    Rat Aplp1 H34623 -
    APP2 Human APLP2 NM_001642 Q06481
    Mouse Aplp2 NM_001102455 Q06335
    Rat Aplp2 XM_343513 P15943