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Amyloid β Peptides

Amyloid β (Aβ) peptides are the major component of amyloid plaques found in the brains of Alzheimer's patients. Aβ is formed from the progressive cleavage of amyloid precursor protein (APP) by β- and γ-secretase. Two Aβ peptides are formed from APP degradation.

Products
Background
Literature (1)
Gene Data

Amyloid β Peptide Modulators
Cat. No. Product Name / Activity
5343 TPPB
APP modulator; also high affinity PKC activator

Amyloid β Peptide Inhibitors
Cat. No. Product Name / Activity
6363 Avagacestat
Highly potent γ-secretase inhibitor; orally bioavailable
2870 BMS 299897
γ-secretase inhibitor; reduces Aβ levels
4924 CEP 1347
Neuroprotective; blocks Aβ-induced cortical neuron apoptosis. Also inhibitor of JNK signaling
2442 CGP 53353
Inhibitor of de novo Aβ42 assembly
2634 DAPT
γ-secretase inhibitor; reduces Aβ42 levels
6779 Davunetide
Highly potent active component of ADNP; prevents amyloid β aggregation; active in vivo
4524 EGCG
β-secretase inhibitor; inhibits formation of amyloid fibrils
2627 L-685,458
Potent and selective γ-secretase inhibitor; inhibits Aβ40 and Aβ42
7081 LY 2886721 Hydrochloride
Inhibits Aβ1-40 and 1-42 production in vitro and in vivo; potent and selective β-secretase inhibitor
4000 MRK 560
γ-secretase inhibitor; attenuates amyloid plaque deposition
5751 PF 3084014 hydrobromide
Potent γ-secretase inhibitor
2408 Ro 90-7501
Inhibitor of Aβ42 fibril formation
6762 Urolithin A
Inhibits amyloid-β fibrillation; also PI 3-K/Akt/mTOR signaling inhibitor

Other
Cat. No. Product Name / Activity
5053 AC 186
Decreases Aβ levels in combination with ACP-105; ERβ agonist
1191 Amyloid β-Peptide (1-40) (human)
Amyloid β-protein fragment
1428 Amyloid β-Peptide (1-42) (human)
Predominant amyloid β-protein fragment
2425 Amyloid β-peptide (1-42) (rat)
Predominant amyloid β-protein fragment
1429 Amyloid β-peptide (25-35) (human)
Human amyloid β-protein fragment functionally required for neurotoxicity
0427 Bromocriptine mesylate
Reduces Aβ levels; D2 and D3 receptor agonist
3945 Colivelin
Neuroprotective peptide; protects against β-amyloid neurotoxicity
4803 CRANAD 2
Near-infrared probe that detects Aβ40 aggregates
5081 J 147
Neuroprotective and neurotrophic compound; reduces Aβ40 and Aβ42 levels
3144 K 114
Amyloid fibril-specific fluorescent dye
6517 Liraglutide
Reduces Aβ and soluble amyloid levels in vivo; also highly potent GLP-1 receptor agonist
4920 Methoxy-X04
Fluorescent amyloid β detector; brain penetrant
1098 Tranilast
Antiallergic; binds to Aβ40 monomers
7659 Verubecestat
Potently reduces Aβ formation in vitro and in vivo; BACE1 and BACE2 inhibitor

Related Targets

    Amyloid β (Aβ) peptides are the major component of amyloid plaques found in the brains of Alzheimer's patients. Aβ is formed from the progressive cleavage of amyloid precursor protein (APP) by β- and γ-secretase. Two Aβ peptides are formed from APP degradation; Aβ40 and Aβ42. Aβ40 is the most abundant form, but Aβ42 is more fibrillogenic, thus is associated with disease states.

    Mutations in APP have been linked to early onset Alzheimer's disease, as proteolytic cleavage of the altered protein increases the levels of Aβ42 relative to Aβ40. Furthermore, Aβ proteins have been associated with other diseases including Lewy body dementia, inclusion body myositis and cerebral amyloid angiopathy.

    Literature for Amyloid β Peptides

    Tocris offers the following scientific literature for Amyloid β Peptides to showcase our products. We invite you to request* your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.

    Alzheimer's Disease Poster

    Alzheimer's Disease Poster

    Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

    Amyloid β Peptide Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    APP1 Human APLP1 NM_001024807 P51693
    Mouse Aplp1 NM_007467 Q03157
    Rat Aplp1 H34623 -
    APP2 Human APLP2 NM_001642 Q06481
    Mouse Aplp2 NM_001102455 Q06335
    Rat Aplp2 XM_343513 P15943