Tranilast

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Cat.No. 1098 - Tranilast | C18H17NO5 | CAS No. 53902-12-8
Description: Antiallergic; inhibits inflammatory mediator release from mast cells
Chemical Name: 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Antiallergic via inhibition of chemical mediator release from mast cells. Shown to be an effective inhibitor of angiogenesis. Demonstrated to antagonize the effects of angiotensin II on human arteries, possibly by an interaction at the level of the AT1 receptor. Inhibits TRPV2-mediated responses; binds to Aβ40 monomers and increases Aβ40 fibrillation.

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Technical Data

M. Wt 327.34
Formula C18H17NO5
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 53902-12-8
PubChem ID 5282230
InChI Key NZHGWWWHIYHZNX-CSKARUKUSA-N
Smiles COC1=CC=C(\C=C\C(=O)NC2=CC=CC=C2C(O)=O)C=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 327.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.05 mL 15.27 mL 30.55 mL
5 mM 0.61 mL 3.05 mL 6.11 mL
10 mM 0.31 mL 1.53 mL 3.05 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hishikawa et al (1996) Tranilast restores cytokine-induced nitric oxide production against platelet derived growth factor in vascular smooth muscle cells. J.Cardiovasc.Pharmacol. 28 200 PMID: 8856474

Isaji et al (1997) Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo. Br.J.Pharmacol. 122 1061 PMID: 9401770

Jin et al (1998) Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin II. Eur.J.Pharmacol. 361 199 PMID: 9865509

Hisanaga et al (2009) Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells. Diabetes. 58 174 PMID: 18984736

Connors et al (2013) Tranilast binds to Aβ monomers and promotes Aβ fibrillation. Biochemistry PMID: 23679559


If you know of a relevant reference for Tranilast, please let us know.

Keywords: Anti-allergic inhibits inhibitors release mast cells Antiangiogenics TRPV2 amyloid beta AB monomers alzheimers amyloidbeta amyloidb amyloidβ Miscellaneous Compounds

Citations for Tranilast

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