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Description: Brain penetrant, NIR aggregation-induced emission active probe for in vivo imaging of Aβ plaques
Chemical Name: Sodium 3-(4-(Dicyanomethylene)-2-(2-(5-(4-(dimethylamino)phenyl)thiophen-2-yl)vinyl)quinolin-1(4H)-yl)propane-1-sulfonate
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity for QM-FN-SO3

QM-FN-SO3 is a near-infrared aggregation-induced emission active probe for in vivo imaging of amyloid β (Aβ) plaques. Brain penetrant. Excitation and emission maxima (λ) are 488 and 680 nm, respectively.

Optical Data for QM-FN-SO3

QM-FN-SO3 Dye Spectra
λabs 488 nm
λem 680 nm
Cell Permeable Yes
Application Confocal imaging of amyloid-beta plaques, in vitro and in vivo

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Technical Data for QM-FN-SO3

M. Wt 564.65
Formula C29H25N4O3S2.Na
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2316820-94-5
PubChem ID 154727758
Smiles CN(C)C1=CC=C(C=C1)C2=CC=C(S2)/C=C/C(N(CCCS(=O)([O-])=O)C3=C/4C=CC=C3)=CC4=C(C#N)/C#N.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for QM-FN-SO3

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.23 50
water 11.29 20

Preparing Stock Solutions for QM-FN-SO3

The following data is based on the product molecular weight 564.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.54 mL 17.71 mL 35.42 mL
2.5 mM 0.71 mL 3.54 mL 7.08 mL
5 mM 0.35 mL 1.77 mL 3.54 mL
25 mM 0.07 mL 0.35 mL 0.71 mL

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References for QM-FN-SO3

References are publications that support the biological activity of the product.

Yan et al (2023) Preparation of near-infrared AIEgen-active fluorescent probes for mapping amyloid-β plaques in brain tissues and living mice. Nat.Protoc. 18 1316 PMID: 36697872

Fu et al (2019) Rational design of near-infrared aggregation-induced-emission-active probes: in situ mapping of amyloid-β plaques with ultrasensitivity and high-fidelity. J.Am.Chem.Soc. 141 3171 PMID: 30632737

Su et al (2022) Strategic design of amyloid-β species fluorescent probes for Alzheimer's disease. ACS Chem.Neurosci. 13 540 PMID: 35132849

If you know of a relevant reference for QM-FN-SO3, please let us know.

Keywords: QM-FN-SO3, QM-FN-SO3 supplier, Alzheimer's, disease, alzheimers, amyloid-β, species, near-infrared, NIR, fluorescent, probes, diagnosis, AB, amyloid-beta, beta-amyloid, aggregates, plaques, amyloidβ, amyloid, beta, brain, penetrant, peptides, Fluorescent, Amyloid, B, Probes, Beta, Peptides, 7958, Tocris Bioscience

Citations for QM-FN-SO3

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Literature in this Area

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Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:

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