J 147

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Cat.No. 5081 - J 147 | C18H17F3N2O2 | CAS No. 1146963-51-0
Description: Neuroprotective and neurotrophic compound; reduces Aβ40 and Aβ42 levels
Chemical Name: 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
Purity: ≥99% (HPLC)
Datasheet
Citations
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Literature

Biological Activity

Potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.

Licensing Information

Sold for research use only under license from the Salk Institute for Biological Studies

Technical Data

M. Wt 350.33
Formula C18H17F3N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1146963-51-0
PubChem ID 25229652
InChI Key HYMZAYGFKNNHDN-SSDVNMTOSA-N
Smiles O=C(C(F)(F)F)N(C2=C(C)C=C(C)C=C2)/N=C/C1=CC=CC(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 35.03 100
DMSO 35.03 100

Preparing Stock Solutions

The following data is based on the product molecular weight 350.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.27 mL 28.54 mL
5 mM 0.57 mL 2.85 mL 5.71 mL
10 mM 0.29 mL 1.43 mL 2.85 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Chen et al (2011) A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. PLoS One 6 e27865 PMID: 22194796

Prior et al (2013) The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimer's.Res.Ther. 5 25 PMID: 23673233

Chiruta et al (2013) Metabolism of a potent neuroprotective hydrazide. Bioorg.Med.Chem. 21 2733 PMID: 23582448


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