Verubecestat

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Description: BACE1 and BACE2 inhibitor
Chemical Name: N-[3-[(5R)-3-Amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for Verubecestat

Verubecestat is a high affinity and selective β-secretase 1 (BACE1) and its homolog BACE2 inhibitor (Ki of 2.2 nM and 0.38 nM respectively). It exhibits no inhibition of cathepsin D, cathepsin E, pepsin, or renin. Verubecestat potently reduces Aβ40 formation in HEK293 APPSwe/Lon cells (IC50 = 2.1 nM). Verubecestat significantly lowers CSF and brain Aβ levels in rats. Orally bioavailable.

Technical Data for Verubecestat

M. Wt 409.41
Formula C17H17F2N5O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1286770-55-5
PubChem ID 51352361
InChI Key YHYKUSGACIYRML-KRWDZBQOSA-N
Smiles C[C@@]1(C2=CC(NC(=O)C3=CC=C(F)C=N3)=CC=C2F)CS(=O)(=O)N(C)C(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Verubecestat

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.94 100
ethanol 8.19 20

Preparing Stock Solutions for Verubecestat

The following data is based on the product molecular weight 409.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.21 mL 24.43 mL
5 mM 0.49 mL 2.44 mL 4.89 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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References for Verubecestat

References are publications that support the biological activity of the product.

Scott et al (2016) Discovery of the 3-imino-1,2,4-thiadiazinane 1,1-dioxide derivative Verubecestat (MK-8931) - A β-site amyloid precursor protein cleaving enzyme 1 inhibitor for the treatment of Alzheimer's disease. J.Med.Chem. 59 10435 PMID: 27933948


If you know of a relevant reference for Verubecestat, please let us know.

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Citations for Verubecestat

Citations are publications that use Tocris products.

Currently there are no citations for Verubecestat. Do you know of a great paper that uses Verubecestat from Tocris? Please let us know.

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