Colivelin

Pricing Availability   Qty
Cat.No. 3945 - Colivelin | Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro | CAS No. 867021-83-8
Description: STAT3 activator; also protects against β-amyloid neurotoxicity
Datasheet
Citations (1)
Reviews
Literature (2)
Pathways (1)

Biological Activity

Neuroprotective peptide and activator of STAT3. Protects neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. Suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer's disease (AD) models. Also prevents alcohol-induced apoptosis in a fetal mouse model. Brain penetrant.

Technical Data

M. Wt 2645.13
Formula C119H206N32O35
Sequence SALLRSIPAPAGASRLLLLTGEIDLP
Storage Store at -20°C
CAS Number 867021-83-8
PubChem ID 90477169
InChI Key PTTAQOYOJJTWFD-IBAOLXMASA-N
Smiles [H]N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in 20% ethanol / water

Product Datasheets

Certificate of Analysis / Product Datasheet
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Keywords: Colivelin, Colivelin supplier, neuroprotectant, neuroprotective, beta-amyloid, b-amyloid, β-amyloid, alzheimers, disease, STAT3, amyloidbeta, amyloidb, amyloidβ, Amyloid, Beta, Peptides, STAT, 3945, Tocris Bioscience

1 Citation for Colivelin

Citations are publications that use Tocris products. Selected citations for Colivelin include:

Vergani et al (2013) Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7. J Cell Biol 127 463 PMID: 23250993


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Pathways for Colivelin

JAK-STAT

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.