PF 3084014 hydrobromide

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Cat.No. 5751 - PF 3084014 hydrobromide | C27H41F2N5O.2HBr | CAS No. 1962925-29-6
Description: Potent γ-secretase inhibitor
Chemical Name: (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 651.47
Formula C27H41F2N5O.HBr
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1962925-29-6
PubChem ID 121513889
InChI Key LXEYYZYDWLAIPW-KBVFCZPLSA-N
Smiles O=C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)[C@H](CCC)N[C@H]2CCC1=CC(F)=CC(F)=C1C2.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 6.51 10 with gentle warming
DMSO 65.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 651.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.53 mL 7.67 mL 15.35 mL
5 mM 0.31 mL 1.53 mL 3.07 mL
10 mM 0.15 mL 0.77 mL 1.53 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Lanz et al (2010) Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 334 269 PMID: 20363853


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Citations for PF 3084014 hydrobromide

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