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PF 3084014 hydrobromide
Biological Activity for PF 3084014 hydrobromide
PF 3084014 hydrobromide is a potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for PF 3084014 hydrobromide
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PF 3084014 hydrobromide
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||6.51||10 with gentle warming|
Preparing Stock Solutions for PF 3084014 hydrobromide
The following data is based on the product molecular weight 651.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.53 mL||7.67 mL||15.35 mL|
|5 mM||0.31 mL||1.53 mL||3.07 mL|
|10 mM||0.15 mL||0.77 mL||1.53 mL|
|50 mM||0.03 mL||0.15 mL||0.31 mL|
Product Datasheets for PF 3084014 hydrobromide
References for PF 3084014 hydrobromide
References are publications that support the biological activity of the product.
Lanz et al (2010) Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 334 269 PMID: 20363853
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Citations for PF 3084014 hydrobromide
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.