PF 3084014 hydrobromide

Pricing Availability Delivery Time Qty
Cat.No. 5751 - PF 3084014 hydrobromide | C27H41F2N5O.2HBr | CAS No. 1962925-29-6
Description: Potent γ-secretase inhibitor
Chemical Name: (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 651.47
Formula C27H41F2N5O.HBr
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1962925-29-6
PubChem ID 121513889
InChI Key LXEYYZYDWLAIPW-KBVFCZPLSA-N
Smiles O=C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)[C@H](CCC)N[C@H]2CCC1=CC(F)=CC(F)=C1C2.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 65.15 100
water 6.51 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 651.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.53 mL 7.67 mL 15.35 mL
5 mM 0.31 mL 1.53 mL 3.07 mL
10 mM 0.15 mL 0.77 mL 1.53 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lanz et al (2010) Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 334 269 PMID: 20363853


If you know of a relevant reference for PF 3084014 hydrobromide, please let us know.

View Related Products by Target

View Related Products by Product Action

View all γ-Secretase Inhibitors

Keywords: PF 3084014 hydrobromide, supplier, PF3084014, hydrobromide, gamma, secretase, inhibitors, inhibits, γ, Abeta, amyloid, β, Gamma-Secretase, Tocris Bioscience

Citations for PF 3084014 hydrobromide

Citations are publications that use Tocris products.

Currently there are no citations for PF 3084014 hydrobromide. Do you know of a great paper that uses PF 3084014 hydrobromide from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Alzheimer's

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

Pathways for PF 3084014 hydrobromide

Protocols

TODO: Add Protocols