PF 3084014 hydrobromide

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Potent γ-secretase inhibitor
Chemical Name: (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for PF 3084014 hydrobromide

PF 3084014 hydrobromide is a potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PF 3084014 hydrobromide

M. Wt 651.47
Formula C27H41F2N5O.HBr
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1962925-29-6
PubChem ID 121513889
Smiles O=C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)[C@H](CCC)N[C@H]2CCC1=CC(F)=CC(F)=C1C2.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PF 3084014 hydrobromide

Solvent Max Conc. mg/mL Max Conc. mM
water 6.51 10 with gentle warming
DMSO 65.15 100

Preparing Stock Solutions for PF 3084014 hydrobromide

The following data is based on the product molecular weight 651.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.53 mL 7.67 mL 15.35 mL
5 mM 0.31 mL 1.53 mL 3.07 mL
10 mM 0.15 mL 0.77 mL 1.53 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for PF 3084014 hydrobromide

References for PF 3084014 hydrobromide

References are publications that support the biological activity of the product.

Lanz et al (2010) Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 334 269 PMID: 20363853

If you know of a relevant reference for PF 3084014 hydrobromide, please let us know.

View Related Products by Product Action

View all γ-Secretase Inhibitors

Keywords: PF 3084014 hydrobromide, PF 3084014 hydrobromide supplier, PF3084014, hydrobromide, gamma, secretase, inhibitors, inhibits, γ, Abeta, amyloid, β, Gamma-Secretase, Amyloid, Beta, Peptides, 5751, Tocris Bioscience

Citations for PF 3084014 hydrobromide

Citations are publications that use Tocris products.

Currently there are no citations for PF 3084014 hydrobromide. Do you know of a great paper that uses PF 3084014 hydrobromide from Tocris? Please let us know.

Reviews for PF 3084014 hydrobromide

There are currently no reviews for this product. Be the first to review PF 3084014 hydrobromide and earn rewards!

Have you used PF 3084014 hydrobromide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products
Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.