Urolithin A

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Cat.No. 6762 - Urolithin A | C13H8O4 | CAS No. 1143-70-0
Description: PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro
Chemical Name: 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

PI 3-K/Akt/mTOR signaling pathway inhibitor; blocks phosphorylation of Akt and p70S6K in pancreatic ductal adenocarcinoma (PDAC). Inhibits proliferation and migration and promotes apoptosis of PDAC cell lines in vitro (IC50 values are 10.23 - 62.28 μM). Suppresses tumor growth and improves survival in mice bearing pancreatic tumor xenografts. Also blocks amyloid-β fibrillation in vitro.

Technical Data

M. Wt 228.2
Formula C13H8O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1143-70-0
PubChem ID 5488186
InChI Key RIUPLDUFZCXCHM-UHFFFAOYSA-N
Smiles OC1=CC=C2C(OC(C3=CC(O)=CC=C23)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.82 100

Preparing Stock Solutions

The following data is based on the product molecular weight 228.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.38 mL 21.91 mL 43.82 mL
5 mM 0.88 mL 4.38 mL 8.76 mL
10 mM 0.44 mL 2.19 mL 4.38 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

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References

References are publications that support the biological activity of the product.

Totiger et al (2019) Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer. Mol.Cancer Ther. 18 301 PMID: 30404927

Yuan et al (2016) Pomegranate's neuroprotective effects against Alzheimer's disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites. ACS Chem.Neurosci. 7 26 PMID: 26559394


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Literature in this Area

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Pathways for Urolithin A

Akt

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.