You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Urolithin A
Urolithin A is a PI 3-K/Akt/mTOR signaling pathway inhibitor; blocks phosphorylation of Akt and p70S6K in pancreatic ductal adenocarcinoma (PDAC). Inhibits proliferation and migration and promotes apoptosis of PDAC cell lines in vitro (IC50 values are 10.23 - 62.28 μM). Suppresses tumor growth and improves survival in mice bearing pancreatic tumor xenografts. Also blocks amyloid-β fibrillation in vitro.
Technical Data for Urolithin A
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Urolithin A
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Urolithin A
The following data is based on the product molecular weight 228.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.38 mL||21.91 mL||43.82 mL|
|5 mM||0.88 mL||4.38 mL||8.76 mL|
|10 mM||0.44 mL||2.19 mL||4.38 mL|
|50 mM||0.09 mL||0.44 mL||0.88 mL|
References for Urolithin A
References are publications that support the biological activity of the product.
Totiger et al (2019) Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer. Mol.Cancer Ther. 18 301 PMID: 30404927
Yuan et al (2016) Pomegranate's neuroprotective effects against Alzheimer's disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites. ACS Chem.Neurosci. 7 26 PMID: 26559394
If you know of a relevant reference for Urolithin A, please let us know.
View Related Products by Target
Keywords: Urolithin A, Urolithin A supplier, UrolithinA, AKt, PI, 3-kinase, PI3K, signaling, inhibitor, inhibits, anticancer, neuroprotectant, protein, kinase, B, PKB, amyloid, beta, β, A-beta, Akt, (Protein, Kinase, B), 3-Kinase, Amyloid, Beta, Peptides, 6762, Tocris Bioscience
Citations for Urolithin A
Citations are publications that use Tocris products.
Currently there are no citations for Urolithin A. Do you know of a great paper that uses Urolithin A from Tocris? Please let us know.
Reviews for Urolithin A
There are currently no reviews for this product. Be the first to review Urolithin A and earn rewards!
Have you used Urolithin A?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.