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PI 3-K/Akt/mTOR signaling pathway inhibitor; blocks phosphorylation of Akt and p70S6K in pancreatic ductal adenocarcinoma (PDAC). Inhibits proliferation and migration and promotes apoptosis of PDAC cell lines in vitro (IC50 values are 10.23 - 62.28 μM). Suppresses tumor growth and improves survival in mice bearing pancreatic tumor xenografts. Also blocks amyloid-β fibrillation in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 228.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.38 mL||21.91 mL||43.82 mL|
|5 mM||0.88 mL||4.38 mL||8.76 mL|
|10 mM||0.44 mL||2.19 mL||4.38 mL|
|50 mM||0.09 mL||0.44 mL||0.88 mL|
References are publications that support the biological activity of the product.
Totiger et al (2019) Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer. Mol.Cancer Ther. 18 301 PMID: 30404927
Yuan et al (2016) Pomegranate's neuroprotective effects against Alzheimer's disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites. ACS Chem.Neurosci. 7 26 PMID: 26559394
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Keywords: Urolithin A, Urolithin A supplier, UrolithinA, AKt, PI, 3-kinase, PI3K, signaling, inhibitor, inhibits, anticancer, neuroprotectant, protein, kinase, B, PKB, amyloid, beta, β, A-beta, Akt, (Protein, Kinase, B), 3-Kinase, Amyloid, Beta, Peptides, 6762, Tocris Bioscience
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Literature in this Area
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Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.