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Potent amyloid fibril-specific fluorescent dye (EC50 = 20 - 30 nM). Exhibits minimal fluorescence in aqueous buffers and fluoresces brightly in the presence of Aβ, α-synuclein and tau in situ. (Optimum wavelength = 550 nm).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 393.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.54 mL||12.71 mL||25.43 mL|
|5 mM||0.51 mL||2.54 mL||5.09 mL|
|10 mM||0.25 mL||1.27 mL||2.54 mL|
|50 mM||0.05 mL||0.25 mL||0.51 mL|
References are publications that support the biological activity of the product.
Crystal et al (2003) A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114. J.Neurochem. 86 1359 PMID: 12950445
LeVine (2005) Mechanism of Aβ(1-40) fibril-induced fluorescence of (trans-trans)-1-bromo-2,5-bis(4-hydroxystyryl)benene (K114). Biochemistry 44 15937 PMID: 16313197
If you know of a relevant reference for K 114, please let us know.
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Keywords: K 114, K 114 supplier, Amyloid, fibril-specific, fluorescent, dye, Fluorescent, Probes, Beta, Precursor, Protein, APP, Secretase, β-Amyloid, beta-Amyloid, b-amyloid, Peptides, K114, amyloidbeta, amyloidb, amyloidβ, B, 3144, Tocris Bioscience
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Literature in this Area
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