You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
LY 2886721 Hydrochloride
Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 426.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.34 mL||11.71 mL||23.43 mL|
|5 mM||0.47 mL||2.34 mL||4.69 mL|
|10 mM||0.23 mL||1.17 mL||2.34 mL|
|50 mM||0.05 mL||0.23 mL||0.47 mL|
References are publications that support the biological activity of the product.
May et al (2015) The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs and humans. J.Neurosci. 35 1199 PMID: 25609634
If you know of a relevant reference for LY 2886721 Hydrochloride, please let us know.
View Related Products by Product Action
Keywords: LY 2886721 Hydrochloride, LY 2886721 Hydrochloride supplier, LY2886721, Hydrochloride, BACE1, BACE2, inhibitors, inhibits, amyloid, beta, β, ab40, ab42, secretase, b-secretase, alzheimers, disease, AD, Other, Proteases, Amyloid, Beta, Peptides, 7081, Tocris Bioscience
Citations for LY 2886721 Hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for LY 2886721 Hydrochloride. Do you know of a great paper that uses LY 2886721 Hydrochloride from Tocris? Please let us know.
Reviews for LY 2886721 Hydrochloride
There are currently no reviews for this product. Be the first to review LY 2886721 Hydrochloride and earn rewards!
Have you used LY 2886721 Hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image