Ro 90-7501

Pricing Availability Delivery Time Qty
Cat.No. 2408 - Ro 90-7501 | C20H16N6 | CAS No. 293762-45-5
Description: Inhibitor of Aβ42 fibril formation
Chemical Name: 2'-(4-Aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM).

Compound Libraries

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Technical Data

M. Wt 340.39
Formula C20H16N6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 293762-45-5
PubChem ID 824226
InChI Key PAGZCEHLFCJSPV-UHFFFAOYSA-N
Smiles NC1=CC=C(C=C1)C1=NC2=CC=C(C=C2N1)C1=NC2=CC=C(N)C=C2N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 3.4 10
DMSO 34.04 100
ethanol 34.04 100

Preparing Stock Solutions

The following data is based on the product molecular weight 340.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.38 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bohrmann et al (2000) Self-assembly of beta-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates. J.Struct.Biol. 130 232 PMID: 10940228


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View all Amyloid β Peptide Inhibitors

Keywords: inhibitors inhibits Aβ4 β42 beta42 fibril formation β-Amyloid beta-Amyloid b-amyloid Precursor Protein APP Secretase beta Peptides Ro90-7501 amyloidbeta amyloidb amyloidβ Amyloid Beta Peptides

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Neurodegeneration

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Alzheimer's

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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

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