Pricing Availability Delivery Time Qty
Cat.No. 5343 - TPPB | C27H30F3N3O3 | CAS No. 497259-23-1
Description: High affinity PKC activator; also APP modulator
Chemical Name: (2E,4E)-N-[(2S,5S)-1,2,3,4,5,6-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3-oxo-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienamide
Purity: ≥98% (HPLC)

Biological Activity

High affinity protein kinase C activator (Ki =11.9 nM). Induces differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. Also enhances secretion of amyloid precursor protein. Cell permeable.

Technical Data

M. Wt 501.54
Formula C27H30F3N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 497259-23-1
PubChem ID 9935767
Smiles CC([C@@H]1N(C2=CC=C(C=C2C[C@H](NC1=O)CO)NC(/C=C/C=C/C3=CC=C(C(F)(F)F)C=C3)=O)C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.08 50

Preparing Stock Solutions

The following data is based on the product molecular weight 501.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.99 mL 9.97 mL 19.94 mL
5 mM 0.4 mL 1.99 mL 3.99 mL
10 mM 0.2 mL 1 mL 1.99 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Rezania et al (2014) Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nat.Biotechnol. 32 1121 PMID: 25211370

Chen et al (2009) A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat.Chem.Biol. 5 258 PMID: 19287398

Kozikowski et al (2003) New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα. J.Med.Chem. 46 364 PMID: 12540236

If you know of a relevant reference for TPPB, please let us know.

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Keywords: TPPB, supplier, PKC, activator, high, affinity, induces, differentiation, Pdx-1, pancreatic, progenitor, amyloid, precursor, protein, cell, permeable, APP, Protein, Kinase, C, Other, Differentiation, Products, Amyloid, Beta, Peptides, Protein, Kinase, C, Tocris Bioscience

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