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Biological Activity for TPPB
TPPB is a high affinity and cell permeable protein kinase C activator (Ki =11.9 nM), which induces differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. TPPB also enhances the non-amyloidgenic processing of amyloid precursor protein, increasing secretion of sAPPα.
Technical Data for TPPB
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TPPB
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TPPB
The following data is based on the product molecular weight 501.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.99 mL||19.94 mL||39.88 mL|
|2.5 mM||0.8 mL||3.99 mL||7.98 mL|
|5 mM||0.4 mL||1.99 mL||3.99 mL|
|25 mM||0.08 mL||0.4 mL||0.8 mL|
References for TPPB
References are publications that support the biological activity of the product.
Rezania et al (2014) Reversal of diabetes with Ins-producing cells derived in vitro from human pluripotent stem cells. Nat.Biotechnol. 32 1121 PMID: 25211370
Chen et al (2009) A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat.Chem.Biol. 5 258 PMID: 19287398
Kozikowski et al (2003) New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα. J.Med.Chem. 46 364 PMID: 12540236
If you know of a relevant reference for TPPB, please let us know.
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6 Citations for TPPB
Citations are publications that use Tocris products. Selected citations for TPPB include:
Kristina G et al (2021) Generation of insulin-producing pancreatic β cells from multiple human stem cell lines. Nat Protoc 16 4109-4143 PMID: 34349281
Robert G et al (2022) Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians. Cells 11 PMID: 35563754
Yang et al (2020) A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell 27 125 PMID: 32579880
Rudolf et al (2020) Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction. Cell Rep Med 1 100097 PMID: 33205073
Kenichiro et al (2020) Bioinformatic Analyses of miRNA-mRNA Signature during hiPSC Differentiation towards Insulin-Producing Cells upon HNF4α Mutation. Biomedicines 8 PMID: 32605028
Leonardo et al (2020) Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells. Nat Biotechnol 38 460-470 PMID: 32094658
Do you know of a great paper that uses TPPB from Tocris? Please let us know.
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Literature in this Area
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