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TPPB is a high affinity and cell permeable protein kinase C activator (Ki =11.9 nM), which induces differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. TPPB also enhances the non-amyloidgenic processing of amyloid precursor protein, increasing secretion of sAPPα.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 501.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.99 mL||19.94 mL||39.88 mL|
|2.5 mM||0.8 mL||3.99 mL||7.98 mL|
|5 mM||0.4 mL||1.99 mL||3.99 mL|
|25 mM||0.08 mL||0.4 mL||0.8 mL|
References are publications that support the biological activity of the product.
Rezania et al (2014) Reversal of diabetes with Ins-producing cells derived in vitro from human pluripotent stem cells. Nat.Biotechnol. 32 1121 PMID: 25211370
Chen et al (2009) A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat.Chem.Biol. 5 258 PMID: 19287398
Kozikowski et al (2003) New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα. J.Med.Chem. 46 364 PMID: 12540236
If you know of a relevant reference for TPPB, please let us know.
Keywords: TPPB, TPPB supplier, PKC, activator, high, affinity, induces, differentiation, Pdx-1, pancreatic, progenitor, amyloid, precursor, protein, cell, permeable, APP, stem, cells, Protein, Kinase, C, Other, Differentiation, Products, Amyloid, Beta, Peptides, 5343, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for TPPB include:
Yang et al (2020) A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell 27 125 PMID: 32579880
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