TPPB

Pricing Availability   Qty
Cat.No. 5343 - TPPB | C27H30F3N3O3 | CAS No. 497259-23-1
Description: High affinity PKC activator; also APP modulator
Chemical Name: (2E,4E)-N-[(2S,5S)-1,2,3,4,5,6-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3-oxo-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity protein kinase C activator (Ki =11.9 nM). Induces differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. Also enhances secretion of amyloid precursor protein. Cell permeable.

Technical Data

M. Wt 501.54
Formula C27H30F3N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 497259-23-1
PubChem ID 9935767
InChI Key WOLVEMPZUIFSII-IHHOKICGSA-N
Smiles CC([C@@H]1N(C2=CC=C(C=C2C[C@H](NC1=O)CO)NC(/C=C/C=C/C3=CC=C(C(F)(F)F)C=C3)=O)C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.08 50

Preparing Stock Solutions

The following data is based on the product molecular weight 501.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.99 mL 19.94 mL 39.88 mL
2.5 mM 0.8 mL 3.99 mL 7.98 mL
5 mM 0.4 mL 1.99 mL 3.99 mL
25 mM 0.08 mL 0.4 mL 0.8 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Rezania et al (2014) Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nat.Biotechnol. 32 1121 PMID: 25211370

Chen et al (2009) A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat.Chem.Biol. 5 258 PMID: 19287398

Kozikowski et al (2003) New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα. J.Med.Chem. 46 364 PMID: 12540236


If you know of a relevant reference for TPPB, please let us know.

View Related Products by Product Action

View all Protein Kinase C Activators

Keywords: TPPB, TPPB supplier, PKC, activator, high, affinity, induces, differentiation, Pdx-1, pancreatic, progenitor, amyloid, precursor, protein, cell, permeable, APP, Protein, Kinase, C, Other, Differentiation, Products, Amyloid, Beta, Peptides, 5343, Tocris Bioscience

Citations for TPPB

Citations are publications that use Tocris products.

Currently there are no citations for TPPB. Do you know of a great paper that uses TPPB from Tocris? Please let us know.

Reviews for TPPB

There are currently no reviews for this product. Be the first to review TPPB and earn rewards!

Have you used TPPB?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling