Selective D2-like dopamine receptor agonist (Ki values are ~ 8, ~ 5, ~ 290, ~ 440 and ~ 450 nM for D2, D3, D4, D1 and D5 receptors respectively).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 750.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.33 mL||6.66 mL||13.32 mL|
|5 mM||0.27 mL||1.33 mL||2.66 mL|
|10 mM||0.13 mL||0.67 mL||1.33 mL|
|50 mM||0.03 mL||0.13 mL||0.27 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Aubner et al (1990) Bromocriptine produces decreases in cocaine self-administration in the rat. Neuropsychopharmacology 3 101 PMID: 2317262
Lieberman and Goldstein (1985) Bromocriptine in Parkinson disease. Pharmacol.Rev. 37 217 PMID: 3901046
Seeman and Van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264 PMID: 7940991
Traub et al (1985) The effects of chronic bromocriptine treatment on behaviour and dopamine receptor binding in the rat striatum. Eur.J.Pharmacol. 118 147 PMID: 3936723
If you know of a relevant reference for Bromocriptine mesylate, please let us know.
View Related Products by Product Action
Keywords: Selective D2-like agonists Dopamine Non-Selective Receptors D3 D4 dopaminergic Non-selective Dopamine
1 Citation for Bromocriptine mesylate
Citations are publications that use Tocris products. Selected citations for Bromocriptine mesylate include:
Jia et al (2013) Age-dependent regulation of synaptic connections by dopamine D2 receptors. Nat Neurosci 16 1627 PMID: 24121738
Do you know of a great paper that uses Bromocriptine mesylate from Tocris? If so please let us know.
Literature in this Area
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.