Bromocriptine mesylate

Pricing Availability Delivery Time Qty
Cat.No. 0427 - Bromocriptine mesylate | C32H40BrN5O5.CH3SO3H | CAS No. 22260-51-1
Description: Selective D2-like agonist
Chemical Name: (5'a)-2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione mesylate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective D2-like dopamine receptor agonist (Ki values are ~ 8, ~ 5, ~ 290, ~ 440 and ~ 450 nM for D2, D3, D4, D1 and D5 receptors respectively).

Compound Libraries

Bromocriptine mesylate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 750.7
Formula C32H40BrN5O5.CH3SO3H
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 22260-51-1
PubChem ID 31100
InChI Key NOJMTMIRQRDZMT-GSPXQYRGSA-N
Smiles [H][C@]4([C@@](N[C@]([C@H](C)C)5C(N([C@@]([H])(CC(C)C)C(N(CCC7)[C@@]76[H])=O)[C@@]6(O)O5)=O)=O)CN([C@](C3=C4)([H])CC1=C(Br)NC2=C1C3=CC=C2)C.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 75.07 100
ethanol 7.51 10

Preparing Stock Solutions

The following data is based on the product molecular weight 750.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.33 mL 6.66 mL 13.32 mL
5 mM 0.27 mL 1.33 mL 2.66 mL
10 mM 0.13 mL 0.67 mL 1.33 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Aubner et al (1990) Bromocriptine produces decreases in cocaine self-administration in the rat. Neuropsychopharmacology 3 101 PMID: 2317262

Lieberman and Goldstein (1985) Bromocriptine in Parkinson disease. Pharmacol.Rev. 37 217 PMID: 3901046

Seeman and Van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264 PMID: 7940991

Traub et al (1985) The effects of chronic bromocriptine treatment on behaviour and dopamine receptor binding in the rat striatum. Eur.J.Pharmacol. 118 147 PMID: 3936723


If you know of a relevant reference for Bromocriptine mesylate, please let us know.

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Keywords: Bromocriptine mesylate, supplier, Selective, D2-like, agonists, Dopamine, Non-Selective, Receptors, D3, D4, dopaminergic, Non-selective, Dopamine, Non-selective, Dopamine, Tocris Bioscience

1 Citation for Bromocriptine mesylate

Citations are publications that use Tocris products. Selected citations for Bromocriptine mesylate include:

Jia et al (2013) Age-dependent regulation of synaptic connections by dopamine D2 receptors. Nat Neurosci 16 1627 PMID: 24121738


Do you know of a great paper that uses Bromocriptine mesylate from Tocris? If so please let us know.

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Pathways for Bromocriptine mesylate

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