CRANAD 2

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Cat.No. 4803 - CRANAD 2 | C23H25BF2N2O2 | CAS No. 1193447-34-5
Description: Near-infrared probe that detects Aβ40 aggregates
Chemical Name: (T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Near-infrared probe that binds to Aβ40 aggregates (Kd = 38 nM) and elicits an emission blue shift. Shown to bind to plaques in APP-PS1 transgenic mice, in vitro. Detects senile plaques in 19-month-old Tg2576 mice in vivo. Penetrates the blood-brain barrier.

Technical Data

M. Wt 410.26
Formula C23H25BF2N2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1193447-34-5
PubChem ID 46861929
InChI Key GNLVJIICVWDSNI-LFYBBSHMSA-N
Smiles CN(C)C(C=C3)=CC=C3/C=C/C1=CC(/C=C/C2=CC=C(N(C)C)C=C2)=[O+][B-](F)(F)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.05 5 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 410.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 48.75 mL 243.75 mL 487.5 mL
0.25 mM 9.75 mL 48.75 mL 97.5 mL
0.5 mM 4.87 mL 24.37 mL 48.75 mL
2.5 mM 0.97 mL 4.87 mL 9.75 mL

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References

References are publications that support the biological activity of the product.

Ran et al (2009) Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J.Am.Chem.Soc. 131 15257 PMID: 19807070

Ran et al (2011) Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species. PLoS One. 6 e19362 PMID: 21559413


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Keywords: CRANAD 2, CRANAD 2 supplier, near-infrared, NIR, probes, AB40, AB, amyloid-beta, beta-amyloid, aggregates, senile, plaques, Tg2576, amyloidb, amyloidβ, Amyloid, Beta, Peptides, Other, Fluorescent, Probes, B, 4803, Tocris Bioscience

Citations for CRANAD 2

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