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Submit ReviewCRANAD 2
Discontinued Product
4803 has been discontinued.
Description: Near-infrared probe that detects Aβ40 aggregates. Used for: amyloid-β detection in vitro and in vivo. Application: fluorescence microscopy, epifluorescence microscopy
Chemical Name: (T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron
Purity: ≥98% (HPLC)
Biological Activity for CRANAD 2
Key information: CRANAD 2 is a curcumin derivatized near-infrared probe that binds to Aβ40 aggregates. Penetrates the blood-brain barrier.
Used for: amyloid- detection in vitro, tissue and in vivo. Shown to bind to plaques in APP-PS1 transgenic mice, in vitro. Detects senile plaques in 19-month-old Tg2576 mice in vivo.
Application: Fluorescence microscopy, epifluorescence microscopy.
Properties and Photophysical Data: CRANAD 2 binds to Aβ40 aggregates (Kd = 38 nM) and elicits upon interacting with Aβ aggregates, an emission blue shift (from 805 nm to 715 nm). When unbound in PBS, excitation and emission maxima (λ) are 640 nm and 805 nm, respectively.
Technical Data for CRANAD 2
| M. Wt | 410.26 |
| Formula | C23H25BF2N2O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1193447-34-5 |
| PubChem ID | 46861929 |
| InChI Key | GNLVJIICVWDSNI-LFYBBSHMSA-N |
| Smiles | CN(C)C(C=C3)=CC=C3/C=C/C1=CC(/C=C/C2=CC=C(N(C)C)C=C2)=[O+][B-](F)(F)O1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CRANAD 2
References for CRANAD 2
References are publications that support the biological activity of the product.
Ran et al (2009) Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J.Am.Chem.Soc. 131 15257 PMID: 19807070
Ran et al (2011) Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species. PLoS One. 6 e19362 PMID: 21559413
Ni et al (2021) In-vitro and in-vivo characterization of CRANAD-2 for multi-spectral optoacoustic tomography and fluorescence imaging of amyloid-beta deposits in Alzheimer mice. Photoacoustics 23 100285 PMID: 34354924
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Keywords: CRANAD 2, CRANAD 2 supplier, near-infrared, NIR, probes, AB40, AB, amyloid-beta, beta-amyloid, aggregates, senile, plaques, Tg2576, amyloidb, amyloidβ, Amyloid, Beta, Peptides, Fluorescent, B, Probes, 4803, Tocris Bioscience
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